Adipose tissue hormones

Česká verzia

Authors: M. Haluzík ¹ ; P. Trachta ¹; D. Haluzíková ^1,2
Authors place of work: III. interní klinika 1. lékařské fakulty UK a VFN Praha, přednosta prof. MU Dr. Štěpán Svačina, DrSc., MBA ¹; Ústav tělovýchovného lékařství 1. lékařské fakulty UK a VFN Praha, přednosta doc. MU Dr. Zdeněk Vilikus, CSc. ²
Published in the journal: Vnitř Lék 2010; 56(10): 1028-1034
Category: Obesity 2010

Summary

Adipose tissue had been traditionally considered a passive energy storage site without direct influence on energy homeostasis regulation. This view has been principally changed during early nineties by the discovery of hormonal production of adipose tissue. At present, the list of hormonally active substances of adipose tissue includes more than one hundred factors with paracrine or endocrine activity that play an important role in metabolic, food intake a inflammatory regulations and many other processes. Only minority of adipose tissue- derived hormones is produced exclusively in fat. Most of these factors is primarily put out by other tissues and organs. Adipose tissue- derived hormones are produced not only by adipocytes but also by preadipocytes, immunocompetent and endothelial cells and other cell types residing in fat. This paper summarizes current knowledge about endocrine function of adipose tissue with special respect to its changes in obesity. It also describes its possible role in the ethiopathogenesis of insulin resistance, atherosclerosis and other obesity‑related pathologies.

Key words:
adipose tissue – endocrine function – leptin – adiponectin – obesity – atherosclerosis

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