Medication treatment of singultus in palliative care

Česká verzia

Authors: Barbora Kováčová
Authors place of work: Obchodně-lékárenský odbor, Klinická farmacie – Lochotín, Fakultní nemocnice Plzeň
Published in the journal: Čas. Lék. čes. 2019; 158: 306-309
Category: Review Article

Summary

Singultus (hiccup) is caused by periodic involuntary spastic contractions of the respiratory muscles followed by a sharp inspiration and early glottis closure. This results in typical "hic" sound. Brief episodes of hiccups are quite common experience in general population, and they do not indicate serious disease nor require medical treatment. If chronic, they pose a significant problem with plethora of negative consequences on patient condition, particularly in palliative care. Treatment options involve many approaches - both nonmedication and medication options. However, there are no large controlled trials resulting in unambiguous recommendations. Current pharmacologic treatment strategies are therefore only based on small studies and case reports and they report more or less successful outcomes using medications with different mechanisms of action.

Keywords:

palliative care – pharmacotherapy – singultus – cancer patient

Zdroje

Hackworth WA, Kimmelshue KN, Stravitz RT. Peritoneal sarcoidosis: a unique cause of ascites and intractable hiccups. Gastroenterol Hepatol 2009; 5(12): 859–861.
Balakrishnan V, Rajesh G. Practical Gastroenterology (2^nd ed.). Jaypee Brothers Medical Publishers, 2016.
Steger M, Schneemann M, Fox M. Systemic review: the pathogenesis and pharmacological treatment of hiccups. Aliment Pharmacol Ther 2015; 42: 1037–1050.
Cherny N, Fallon M, Kaasa S et al. Oxford Textbook of Palliative Medicine (5^th ed.). Oxford University Press, 2015.
Lembo AJ. Hiccups. UpToDate, 2018 Oct 02.
Cole JA, Plewa MC. Singultus (Hiccups). StatPearls Publishing, 2019.
Vardy J, Chiew KS, Galica J et al. Side effects associated with the use of dexamethasone for prophylaxis of delayed emesis after moderately emetogenic chemotherapy. Br J Cancer 2006; 94: 1011–1015.
Lee GW, Oh SY, Kang MH et al. Treatment of dexamethasone-induced hiccup in chemotherapy patients by methylprednisolone rotation. Oncologist 2013; 18: 1229–1234.
Baethge BA, Lidsky MD. Intractable hiccups associated with high-dose intravenous methylprednisolone therapy. Ann Intern Med 1986; 104: 58–59.
Calsina-Berna A, García-Gómez G, González-Barboteo J et al. Treatment of chronic hiccups in cancer patients: a systematic review. J Palliat Care 2012; 15(10): 1142–1150.
Turner BB, Weaver DA. Sexual dimorphism of glucocorticoid binding in rat brain. Brain Res 1985; 343: 16–23.
Hosoya R, Uesawa Y, Ishii-Nozawa R et al. Analysis of factors associated with hiccups based on the Japanese Adverse Drug Event Report database. PLoS One 2017; 12(2): e0172057.
Moretto EN, Wee B, Wiffen PJ, Murchison AG. Interventions for treating persistent and intractable hiccups in adults. Cochrane Database Syst Rev 2013; 1: CD008768.
Irwing SA, Iglewicz A, Nelesen RA et al. daily oral ketamine for the treatment of depression and anxiety in patients receiving hospice care: a 28-day open-label proof-of-concept trial. J Palliat Med 2013; 16(8): 958–965.
Woelk C. Managing hiccups. Can Fam Physician 2011; 57: 672–675.
Eisenacher A, Spiske J. Case report: Persistent hiccups (singultus) as the presenting symptom of medullary cavernoma. Dtsch Arztebl Int 2011; 108(48): 822–826.
BNF 76: September 2018 – March 2019. Royal Pharmaceutical Society. Pharmaceutical Press, London, 2019.
Sweetman SC. Martindale: The Complete Drug Reference (36^th ed.). Pharmaceutical Press, 2009.
Waller DG, Sampson AP, Renwock AG et al. Medical Pharmacology & Therapeutics (4^th ed.). Elsevier, 2014.
Skála B, Sláma O, Vorlíček J, Misconiová B. Paliativní péče o pacienty v terminálním stádiu nemoci. Doporučený diagnostický a léčebný postup pro všeobecné praktické lékaře. Společnost všeobecného lékařství ČLS JEP, 2005.
Tegeler ML, Baumrucker SJ. Gabapentin for intractable hiccups in palliative care. Am J Hosp Palliat Care 2008; 25: 52–54.
Groninger H, Cheng MJ. A case of persistent hiccups successfully managed with pregabalin. Prog Palliat Care 2014; 23 (4): 224–226.
Jatzko A, Steigmeier Petroianu A, Petroianu GA. Alpha-2-delta ligands for singultus (hiccup) treatment: three case reports. J Pain Symptom Manage 2007; 33(6): 756–760.
Ramirez FC, Graham DY. Treatment of intractable hiccup with baclofen: results of a double-blind randomised, controlled, cross-over study. Am J Gastroenterol 1992; 87(12): 1789–1791.
Sampath V, Gowda MR, Vinay HR et al. Persistent hiccups (singultus) as the presenting symptom of lateral medullary syndrome. Indian J Psychol Med 2014; 36: 341–343.
Thompson AN, Ehret Leal J, Brzezinski WA. Olanzapine and baclofen for the treatment of intractable hiccups. Pharmacotherapy 2014; 34: e4.

Štítky

Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist

Článek Clinical pharmacy in the Czech Republic

Článek Is safe pharmacotherapy worthwhile?

Článek Specialization in clinical pharmacy

Článek Paediatric clinical pharmacist: a potential benefit?

Článek Drug administration via feeding tubes: examples, working group

Článek Proton pump inhibitors from clinical pharmacist’s point of view

Článek Clinically significant drug interactions of antiretrovirals

Článek Intrapleural alteplase therapy: what are the knowns and unknowns?

Článek Management of metabolic adverse effects of everolimus in patients with renal carcinoma

Článek Combination of mirtazapine and paroxetine: possible clinically demonstrated interaction?

Článek Complication during hospitalization of geronto-psychiatric patient for fatal Stevens-Johnson syndrome – a multidisciplinary approach

Článek Sleep and its disturbances in neurology