Intrapleural alteplase therapy: what are the knowns and unknowns?

Česká verzia

Authors: Judita Staša ¹; Jana Gregorová ^1,2; Norbert Pauk ³
Authors place of work: Oddělení klinické farmacie, Nemocnice Na Bulovce, Praha ¹; Ústav aplikované farmacie, Farmaceutická fakulta VFU Brno ²; Klinika pneumologie 3. LF UK a Nemocnice Na Bulovce, Praha ³
Published in the journal: Čas. Lék. čes. 2019; 158: 295-299
Category: Review Article

Summary

In pneumology, enzymatic properties of plasmin are used to disrupt fibrin adhesions and septations formed during pathological conditions of the pleural cavity. In that case, fibrinolytics are administrated locally via a chest tube in the pleural cavity to evacuate pathological effusion. Although the first intrapleural administration of fibrinolytic occurred seventy years ago, there has been no consensus on dosing or a uniform procedure of their application. The aim of the article is to summarize current knowledge of alteplase usage in pneumology and discuss practical aspects of its intrapleural application regarding specific possibilities in the Czech Republic.

Keywords:

intrapleural fibrinolytics – alteplase – pleural infection – fibrinolytic therapy

Zdroje

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