Clinically significant drug interactions of antiretrovirals

Česká verzia

Authors: Irena Murínová ^1,2
Authors place of work: Oddělení klinické farmacie, Ústřední vojenská nemocnice – Vojenská fakultní nemocnice, Praha ¹; Ústav aplikované farmacie, Farmaceutická fakulta VFU, Brno ²
Published in the journal: Čas. Lék. čes. 2019; 158: 289-294
Category: Review Article

Summary

Evaluating of the clinical significance of drug interactions is one of the domains of clinical pharmacist expertise. Drug interactions are discussed when two or more drugs co-administer and the effect of one of them changes. Drug interactions can be a serious cause of toxicity and side effects. They can also lead to the failure of the treatment. On the other hand, they can also play a positive role, e. g. in the treatment of people living with HIV. The combination of some antiretrovirals with boosters is based on the principle of drug interaction.

The article presents pharmacokinetic drug interactions of antiretrovirals. Their occurrence is not unique in the clinical practice. The pharmacokinetic profiles of the individual antiretrovirals, whose knowledge is essential for the correct assessment of the clinical significance of drug interactions, are reviewed.

Keywords:

clinical pharmacist – HIV – pharmacokinetics – Drug interactions – antiretrovirals

Zdroje

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Štítky

Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist

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