Statins and liver

Česká verzia

Authors: Jiří Hlušička ¹; Mahak Arora ²; Radan Brůha ¹; Aleš Žák ¹
Authors place of work: 4. interní klinika – klinika gastroenterologie a hepatologie 1. LF UK a VFN v Praze ¹; Farmakologický ústav 1. LF UK a VFN v Praze ²
Published in the journal: Čas. Lék. čes. 2022; 161: 80-83
Category: Review Article

Summary

Statins are widely accepted hypolipidemics that work by inhibiting hydroxymethylglutaryl coenzyme A reductase and thereby inhibiting cholesterol synthesis. They significantly reduce cardiovascular risk. Their use could be associated with side effects, which are serious only in rare cases. However, an unhealthy lifestyle, obesity, and elevation of blood lipids do not only damage the cardiovascular system. The current topic not only in hepatology is non-alcoholic fatty liver disease – NAFLD. The aim of this article is, among others, to draw attention to the pleiotropic effects of statins, which could be used in the treatment of this disease in the future. Recent studies have suggested that the administration of statins to patients with NAFLD is beneficial.

Keywords:

NAFLD – statins – hepatopathy

Zdroje

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Štítky

Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist

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