Selenium Supplementation in Patients with Severe Acute Pancreatitis

Česká verzia

Authors: L. Kočan; J. Firment; J. Šimonová; J. Vašková; J. Guzy
Authors place of work: Slovenská republika, prednosta kliniky: doc. MUDr. Jozef Firment, Ph. D. ; I. klinika anesteziológie a intenzívnej medicíny, Univerzálna nemocnica L. Pasteura, Košice
Published in the journal: Rozhl. Chir., 2010, roč. 89, č. 8, s. 518-521.
Category: Monothematic special - Original

Summary

Selenium supplementation improves antioxidant status in critically ill patients with severe acute pancreatitis. It depends on quantum of dosage and supplementation time. The aim of this analysis is point out on benefit of antioxidant therapy by supplementing selenium.

Methods:
Patient with severe acute pancreatitis and developing septic shock was admitted on anesthesiology and intensive care department. Adjuvant supplementation therapy with selenium was started in continual infusion 750 mg/24 h during next six days. Activity of antioxidant enzyme glutathione peroxidase and others inflammatory markers were decrease.

A case report presents the possibility to affect on systemic inflammatory response syndrome pathogenesis in initial phase. It has to improve therapeutic progress in patients with severe acute pancreatitis.

Key words:
severe acute pancreatitis – sepsis – systemic inflammatory response syndrome – selenium – glutathione peroxidase

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