Pharmacological influencing of abdominal aortic aneurysm model – animal experimental study, primary results
Authors:
K. Houdek 1; J. Moláček 1; V. Třeška 1; Z. Tonar 2; V. Křížková 2; L. Eberlová 2; J. Baxa 3; J. Kobr 4
Authors place of work:
Chirurgická klinika LF UK a FN v Plzni, přednosta: Prof. MUDr. V. Třeška, CSc.
1; Ústav histologie a embryologie LF UK v Plzni, vedoucí: Doc. MUDr. M. Králíčková, Ph. D.
2; Klinika zobrazovacích metod LF UK a FN v Plzni, přednosta: Doc. MUDr. B. Kreuzberg, CSc.
3; Dětská klinika LF UK a FN v Plzni, přednosta: Doc. MUDr. J. Kobr, Ph. D.
4
Published in the journal:
Rozhl. Chir., 2012, roč. 91, č. 9, s. 475-480.
Category:
Original articles
Práce vznikla v rámci programového projektu lékařského výzkumu a vývoje podpořeného IGA MZ. Číslo projektu: NS10235-3/2009
Summary
Introduction:
The aim of our work was to influence growth and histological changes in the wall of an experimentally induced aneurysm of the abdominal aorta in a large laboratory animal (domestic pig) by administering atorvastatin (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor).
Material and methods:
Within the scope of the above mentioned experimental work, we compared the growth rate of the aneurysm between the group influenced by statin administration (n=14) and the group without any pharmacological treatment (n=13). We also compared histological changes in the structure of the aortic wall in both groups with aneurysm and the wall of the aorta without aneurysm (n=6).
Results:
During the 4-week follow-up, we did not prove a statistically significant difference in the growth rate of aneurysms between the above mentioned groups. The histological structure of the aneurysm walls, however, differed between the two groups. The structure of the wall in the group of animals influenced by statin administration resembled the structure of the aortic wall without aneurysm.
Conclusion:
The results presented demonstrate that statins do influence the composition of the aortic wall. In our opinion, the administration of statins could lead to changes resulting in a more stable aneurysmatic wall. We believe that patients with smaller aneurysms who are not indicated for surgery or endovascular treatment could be treated with statins. Stabilization of the aneurysmal wall could slow down the growth of the aneurysm and prevent its rupture.
Key words:
Aneurysm – statins – experimental model
Zdroje
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Štítky
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