¹³C-methacetinový dechový test u pacientů s jaterní cirhózou a dekompenzovaným srdečním selháním

Česká verzia

Authors: Jana Vránová ¹; Jozef Rosina ¹; Miluše Hendrichová ²; Antonín Vrána ³; Karolína Krátká ²; Jiří Horák ²
Authors place of work: Ústav lékařské biofyziky a lékařské informatiky, 3. lékařská fakulta, Univerzita Karlova ¹; I. interní klinika, 3. lékařská fakulta, Univerzita Karlova, Praha, Česká republika ²; Ústav radiační onkologie, Nemocnice na Bulovce, Praha, Česká republika ³
Published in the journal: Lékař a technika - Clinician and Technology No. 1, 2013, 43, 24-34
Category: Original research

Summary

An overview of new diagnostic device (Wagner Analysen Technik, Germany) is provided. This device uses the ¹³C stable isotope together with non-dispersive infrared selective spectroscopy for non – invasive quantification of hepatic function parameters, including kinetics (type of liver damage) and capacity (percentage of recovery yield of the liver). The short physical principle of infrared spectroscopy and acousto-optical detector of IRIS was presented. In the final section we verified the diagnostic quality of this new diagnostic device (using ANOVA and ROC analysis) on cohort of 103 patients divided into 3 groups according to diagnosis and the various level of liver damage.

Keywords:
¹³C-methacetin, dose, cumulative dose, infrared spectroscopy, transmitance, absorbance, cirrhosis

Zdroje

[1] Vránová, J., Rosina, J., Horák, J., Krátká, K., Hendrichová, M. Isotope-Selective Infrared Spectroscopy Reveals Pathological Changes in the Liver. Acta Mechanica Slovaca, 2010, vol. 14. no. 2, p. 62-67.

[2] Breath testing in clinical Diagnose [online] [cit 2010-06-18], http://www.wagner-bremen.de/

[3] Petrolati, A., Festi, D., De Berardinis, G., Colaiocco-Ferrante, L., Di Paolo, D., Tisone, G., Angelico, M. 13C-Methacetin Breath Test For Monitoring Hepatic Function in Cirrhotic Patients Before and After Liver Transplantation, Aliment Phramcol. Ther. 2004 Jan 15; vol. 19 no. 2, p. 243.

[4] Infrared Spectroscopy [online], [cit 2010-06-16], Faculty of Education, Charles University in Prague, Chemistry & Chemistry Didactics Dept., downloadable materials: http://userweb.pedf.cuni.cz/kch/downloads/materialy/INA/ICSpektroskopie.pdf

[5] Absorbance [online], [cit 2010-06-18], from Wikipedia, the free encyclopedia, http://cs.wikipedia.org/wiki/Absorbance

[6] Lucero, D. P. An analytical model of the pneumatic nondispersive infrared detector, J. Phys. E. 1973; vol. 6, p. 281-5.

[7] Wai, C.T., Greenson, J.K., Fontana, R.J., Kalbfleisch, J.D., Marrero, J.A., Conjeevaram, H.S., et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology 2003, vol. 38, p. 518–26.

[8] Snyder, N., Gajula, L., Xiao, S.Y., Grady, J., Luxon, B., Lau, D.T. et al. APRI: An easy and validated predictor of hepatic fibrosis in chronic hepatitis C, J Clin Gastroenterol 2006, vol. 40, p. 535–42.

[9] Hendrichova, M., Malek, F., Kratka, K., Sedlakova, M., Vranova, J., Horak, J. Microsomal liver function in patients with liver cirrhosis and chronic heart failure assessed with the 13C-methacetin breath test, Ces a Slov Gastroent a Hepatol 2006, 60 (Supp l1), pages 109.

[10] Málek, F., Havrda, M., Frühaufová, Z., Vránová, J. Multidisciplinární přístup v péči o nemocné s kardiorenálním syndromem – první zkušenosti. Abstrakty, Echodny 2006, 21.9.-23.9.2006. Cor Vasa 2006, vol. 48, no. 9: Kardio K 185.

[11] Hendrichová, M., Málek, F., Kopřivová, H., Vránová, J., Ošťádal, P., Krátká, K., Sedláková, M., Horák, J. Correlation of NT-proBNP with metabolic liver function as assessed with 13C-methacetin breath test in patients with acute decompensated heart silure. International Journal of Cardiology 2010; vol. 144 no. 2, p. 321-2.

[12] Hanley, J.A., McNeil, B.J. A Method of Comparing the Areas under the Receiver Operating Curves Derived from the Same Cases, Radiology 1983 Vol. 148, p. 839-843.