Specific behaviour of the blood sedimentation processes examined by the electrochemical impedance microsensor

Česká verzia

Authors: Štefan Durdík ¹; Vladimír Tvarožek ²; Soňa Flickyngerová ²; Daniel Donoval ²
Authors place of work: Oncology Institute of Santa Elizabeth, Bratislava, Slovakia ¹; Institute of Electronics and Photonics FEI, Slovak University of Technology, Bratislava, Slovakia ²
Published in the journal: Lékař a technika - Clinician and Technology No. 1, 2013, 43, 39-43
Category: Original research

Summary

Electrochemical impedance microsensor for the fast monitoring of the blood sedimentation has been developed. Planar microsensor consisted of the interdigital array of electrodes (IDAE - finger/gap widths of different values from 5/5 μm to 400/400 μm) based on Au or Pt thin films sputtered on Si/SiO₂ or ceramic alumina substrates. IDAE microsensor allows time measurements of electrical impedance changes - impedance rates - (at frequencies of order 0.1 kHz and 10 kHz) of small blood drop applied on it. The determination of the impedance rate during sedimentation and the impedance spectrometry at a low-frequency range of order of 1 kHz seems to be very helpful for a quick diagnostics of the health state. In the IDAE microsensor erythrocyte aggregation/rapid settling/packing periods associated with dry-period are overlapping due to the planar arrangement of dimensions in order of 1 -100 μm. The time monitoring of the blood sedimentation (in the range of 10‑900 seconds) by the impedance method can distinguish between healthy and cancer state of blood and could serve for the simple long-term diagnostics after the surgical operation or as a screening procedure for early diagnoses.

Keywords:
planar IDAE impedance microsensor, blood sedimentation

Zdroje

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