Sevofluran

Česká verzia

Authors: V. Dostálová
Authors place of work: Fakultní nemocnice Hradec Králové ; Univerzita Karlova ; Lékařská fakulta v Hradci Králové ; Klinika anesteziologie, resuscitace a intenzivní medicíny
Published in the journal: Anest. intenziv. Med., 31, 2020, č. Supplementum A, s. 7-13

Summary

Sevoflurane is a halogenated inhalational anesthetic used for the induction and maintenance of general anesthesia in adults and pediatric patients for inpatient and outpatient surgery. Sevoflurane is a volatile anesthetic that provides hypnosis, amnesia, analgesia, immobilization, and autonomic blockade during surgical and procedural interventions It is a volatile, non- -flammable, and non-irritant compound with a low solubility and blood-to-gas partition coefficient. Sevoflurane enhances inhibitory postsynaptic channel activity on gamma-aminobutyric acid and glycine and inhibits excitatory synaptic channel aktivity on N-methyl-D-aspartate, nicotinic acetylcholine, serotonine, and glutamate receptors in the central nervous system. Sevoflurane is delivered to the respirátory systém via a sevoflurane specific calibrated vaporizer attached to an anesthesia machine. Sevoflurane undergoes minimal hepatic metabolism or renal excretion.

Keywords:

sevoflurane – inhalation anesthetics

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