Desfluran

Česká verzia

Authors: D. Mach
Authors place of work: ARO, NIP & Urgentní příjem, Nemocnice Nové Město na Moravě, p. o.
Published in the journal: Anest. intenziv. Med., 31, 2020, č. Supplementum A, s. 14-16

Summary

Desflurane is a halogenated inhalation general anaesthetic agent with low solubility in blood and body tissues, and approximately one-fifih the potency of isoflurane. The low solubility of desflurane facilitates a rapid induction of anaesthesia and precise control of the depth of anaesthesia. Transient airway irritant effects are the most common adverse events during induction of anaesthesia with desflurane; therefore, this agent is not recommended for induction of anaesthesia in paediatric patients. Overall it embodies many of the desirable features of an ideal agent, which include stability to chemical degradation, low solubility in blood and body tissues, negligible metabolism and low potential for hepatorenal toxicity. These favourable physical and pharmacokinetic characteristics should present desflurane as a valuable inhalation anaesthetic agent for the maintenance of general anaesthesia in ambulatory surgery as well as in nonambulatory surgical procedures.

Keywords:

inhalation anaesthetics – desflurane

Zdroje

Brunton Laurence L. Goodman Gilmann’s The Phar-macological Basis of Therapeutics, Twelfth Edition 2011, McGrawHill , ISBN 978-0-07-162442-8.
Miller I, Ronald D. Miller’s anesthesia. Eighth edition. 2015. Philadelphia. Elsevier Inc.ISBN 978-0-323-31479-4.Barash PG, Cullen BF, Stoelting RK. Klinická anesteziologie. 6.vydání. Praha: Grada;2015, ISBN: 978-80-247-4053-9.
Larsen R. Anestezie. 7.vydání. Grada Publishing; 2004, ISBN80-247-0476-5.
Wang L, Cai Y. Effect of administration time in obese patients on speed of recovery and risk of rehypnotization following recovery from different inhaled anesthetics: a computational simulation. Int J Clin Exp Med. 2018;11(6):5548-5555.
Butterworth JF, Mackey DC, Wasnick JD. Morgan and Mikhail’s Clinical Anesthesiology. McGraw-Hill Education; 2018.
Chen G, Zhou Y, Shi Q, Zhou H. Comparison of early recovery and cognitive function after desflurane and sevoflurane anaesthesia in elderly patients: a meta-analysis of randomized controlled trials. J Int Med Res. 2015;43(5):619–628. doi: 10.1177/0300060515591064.