CDED diet in induction therapy of Crohn’s disease

Česká verzia

Authors: Mitrová K.
Authors place of work: Klinické a výzkumní centrum pro střevní záněty ISCARE I. V. F. a. s., Praha ; Pediatrická klinika 2. LF UK a FN Motol, Praha
Published in the journal: Gastroent Hepatol 2019; 73(6): 476-480
Category: Dětská gastroenterologie a hepatologie: přehledová práce
doi: https://doi.org/10.14735/amgh2019476

Summary

The incidence of inflammatory bowel disease (IBD) is increasing. Despite its exact etiopathogenetic mechanism being presently unknown, both genetic and environmental factors are clearly involved.The microbiome and increased intestinal permeability may be important in the development of IBD. Changes in diet and industrial food processing may alter the microbiome and damage intestinal mucosal barrier function, leading to a pathological immune response to intestinal antigens. The hypothesis, that diet plays an important role in the pathogenesis of Crohn’s disease (CD) is supported by findings showing that exclusive enteral nutrition (EEV), with the complete exclusion of a normal diet, leads to healing of the mucosa and remission of the disease. Efforts to find a diet that could cause changes to the mucosa comparable to those of EEV led to the creation of a special elimination diet, the Crohn’s disease exclusion diet (CDED).

Submitted: 19. 11. 2019

Accepted: 3. 12. 2019

Conflict of Interest: The author declares that the article/ manuscript complies with ethical standards, patient anonymity has been respected, and she states that she has no financial, advisory or other commercial interests in relation to the subject matter.

Publication Ethics: This article/ manuscript has not been published or is currently being submitted for another review. The author agrees to publish her name and e-mail in the published article/ manuscript.

Dedication: The article/ manuscript is not supported by a grant nor has it been created with the support of any company.

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for bio medical papers.

Keywords:

Diet – Crohn’s disease – Microbiome – enteral nutrition

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