Primary large cell neuroendocrine carcinoma of the urinary bladder

Česká verzia

Authors: Jirka Mačák ¹; Pavel Dundr ²; Jana Dvořáčková ^1,3; Petr Buzrla ¹; David Němec ⁴
Authors place of work: Ústav patologie, Lékařská fakulta Ostravské univerzity a Fakultní nemocnice Ostrava, Česká republika ¹; Ústav patologie, 1. lékařská fakulta Karlovy univerzity v Praze a Všeobecná fakultní nemocnice v Praze Česká republika ²; CGB laboratoř a. s. Ostrava, Česká republika ³; Urologické oddělení, Fakultní nemocnice Ostrava, Česká republika ⁴
Published in the journal: Čes.-slov. Patol., 49, 2013, No. 2, p. 80-83
Category: Původní práce

Summary

Large cell neuroendocrine carcinoma of the urinary bladder is rare. In the last five years, we have had the opportunity to see this type of cancer in an 88-year-old and in a 66-year-old males. In both cases, transurethral resection of carcinoma of the bladder was carried out. In the first case, urothelial carcinoma was detected and deeper in the bladder wall, large cell neuroendocrine carcinoma structures were found. In the second case, the bladder was only infiltrated with large cell neuroendocrine carcinoma. Both tumors expressed NSE, CD56 and synaptophysin. Other markers, such as those against calcitonin, chromogranin, PP, VIP, serotonin, gastrin, glucagon and somatostatin did not react with the tumor.

In the first case, no tumor dissemination was found; in the second case, clinical methods confirmed dissemination into the liver, left adrenal gland, spleen and paracaval lymph nodes. Given his age, the first patient only received symptomatic therapy. The other patient underwent chemotherapy and his condition is stable. Paraneoplastic manifestations of the tumors were not clinically found.

Histogenetic origin of neuroendocrine tumors is not fully clarified. In some cases, tumor development is thought to be associated with Brunn’s nests, cystitis cystica and urothelial carcinoma stem cells.

Keywords:
primary large cell neuroendocrine carcinoma – urinary bladder – immunohistochemistry

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