Subependymálny obrovskobunkový astrocytóm s atypickými klinickými a patologickými črtami: diagnostická pasca

Subependymálny obrovskobunkový astrocytóm (SEGA) je benígny pomaly rastúci tumor asociovaný so syndrómom tuberóznej sklerózy. Vyskytuje sa takmer výlučne v oblasti foramen Monro. Šírene do parenchýmu hemisféry a znepokojujúce histologické črty ako sú nekrózy, mitózy, mikrovaskulárna proliferácia a pleomorfia sú nezvyčajné, ale vzácne môžu byť prítomné. Prezentujeme prípad SEGA u pacienta, u ktrorého zatiaľ nie sú prítomné ďalšie známky syndrómu tuberóznej sklerózy, s atypickým radiologickým nálezom a mikroskopicky prítomnými nekrózami. Tieto znepokojujúce črty iniciálne viedli k nesprávnej diagnóze glioblastómu. Je diskutovaná diferenciálna diagnóza SEGA.

Kľúčové slová:
subependymálny obrovskobunkový astrocytóm – atypický – nekróza

Autoři: Marián Švajdler jr. ¹; Ladislav Deák ²; Boris Rychlý ³; Peter Talarčík ³; Lucia Fröhlichová ¹
Působiště autorů: Department of pathology, L. Pasteur’s University Hospital, Košice, Slovakia ¹; Department of pediatric oncology and haematology, Children’s University Hospital, Košice, Slovakia ²; Cytopathos s. r. o., Bratislava, Slovakia ³
Vyšlo v časopise: Čes.-slov. Patol., 49, 2013, No. 2, p. 76-79
Kategorie: Původní práce

Souhrn

Kľúčové slová:
subependymálny obrovskobunkový astrocytóm – atypický – nekróza

Zdroje

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