Human and Non-Human Primate Genomes Share Hotspots of Positive
Selection
Among primates, genome-wide analysis of recent positive selection is currently
limited to the human species because it requires extensive sampling of genotypic
data from many individuals. The extent to which genes positively selected in
human also present adaptive changes in other primates therefore remains unknown.
This question is important because a gene that has been positively selected
independently in the human and in other primate lineages may be less likely to
be involved in human specific phenotypic changes such as dietary habits or
cognitive abilities. To answer this question, we analysed heterozygous Single
Nucleotide Polymorphisms (SNPs) in the genomes of single human, chimpanzee,
orangutan, and macaque individuals using a new method aiming to identify
selective sweeps genome-wide. We found an unexpectedly high number of
orthologous genes exhibiting signatures of a selective sweep simultaneously in
several primate species, suggesting the presence of hotspots of positive
selection. A similar significant excess is evident when comparing genes
positively selected during recent human evolution with genes subjected to
positive selection in their coding sequence in other primate lineages and
identified using a different test. These findings are further supported by
comparing several published human genome scans for positive selection with our
findings in non-human primate genomes. We thus provide extensive evidence that
the co-occurrence of positive selection in humans and in other primates at the
same genetic loci can be measured with only four species, an indication that it
may be a widespread phenomenon. The identification of positive selection in
humans alongside other primates is a powerful tool to outline those genes that
were selected uniquely during recent human evolution.
Vyšlo v časopise:
Human and Non-Human Primate Genomes Share Hotspots of Positive
Selection. PLoS Genet 6(2): e32767. doi:10.1371/journal.pgen.1000840
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pgen.1000840
Souhrn
Among primates, genome-wide analysis of recent positive selection is currently
limited to the human species because it requires extensive sampling of genotypic
data from many individuals. The extent to which genes positively selected in
human also present adaptive changes in other primates therefore remains unknown.
This question is important because a gene that has been positively selected
independently in the human and in other primate lineages may be less likely to
be involved in human specific phenotypic changes such as dietary habits or
cognitive abilities. To answer this question, we analysed heterozygous Single
Nucleotide Polymorphisms (SNPs) in the genomes of single human, chimpanzee,
orangutan, and macaque individuals using a new method aiming to identify
selective sweeps genome-wide. We found an unexpectedly high number of
orthologous genes exhibiting signatures of a selective sweep simultaneously in
several primate species, suggesting the presence of hotspots of positive
selection. A similar significant excess is evident when comparing genes
positively selected during recent human evolution with genes subjected to
positive selection in their coding sequence in other primate lineages and
identified using a different test. These findings are further supported by
comparing several published human genome scans for positive selection with our
findings in non-human primate genomes. We thus provide extensive evidence that
the co-occurrence of positive selection in humans and in other primates at the
same genetic loci can be measured with only four species, an indication that it
may be a widespread phenomenon. The identification of positive selection in
humans alongside other primates is a powerful tool to outline those genes that
were selected uniquely during recent human evolution.
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