Exposure Patterns Driving Ebola Transmission in West Africa: A Retrospective Observational Study

1. Gire SK, Goba A, Andersen KG, Sealfon RS, Park DJ, Kanneh L, et al. Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak. Science. 2014;345(6202):1369–72. doi: 10.1126/science.1259657 25214632.

2. Baize S, Pannetier D, Oestereich L, Rieger T, Koivogui L, Magassouba N, et al. Emergence of Zaire Ebola virus disease in Guinea. N Engl J Med. 2014;371(15):1418–25. doi: 10.1056/NEJMoa1404505 24738640.

3. Borchert M, Mutyaba I, Van Kerkhove MD, Lutwama J, Luwaga H, Bisoborwa G, et al. Ebola haemorrhagic fever outbreak in Masindi District, Uganda: outbreak description and lessons learned. BMC Infect Dis. 2011;11:357. doi: 10.1186/1471-2334-11-357 22204600; PubMed Central PMCID: PMC3276451.

4. Breman J, Piot P, Johnson K, White M, Mbuyi M, Sureau P, et al. The epidemiology of Ebola hemorrhagic fever in Zaire, 1976. In: Pattyn SR, editor. Ebola virus haemorrhagic fever. Amsterdam: Elsevier; 1978. pp. 103–24.

5. Commission International. Ebola haemorrhagic fever in Zaire, 1976. Bull World Health Organ. 1978;56(2):271–93. 307456

6. Ebola haemorrhagic fever in Sudan, 1976. Report of a WHO/International Study Team. Bull World Health Organ. 1978;56(2247–70).

7. Alexander K, Sanderson C, Marathe M, Lewis B, Rivers C, Shaman J, et al. What factors might have led to the emergence of Ebola in West Africa. PLoS Negl Trop Dis. 2015;9(6):e0003652. doi: 10.1371/journal.pntd.0003652 26042592

8. Chan M. Ebola virus disease in West Africa—no early end to the outbreak. N Engl J Med. 2014;371(13):1183–5. doi: 10.1056/NEJMp1409859 25140856

9. World Health Organization. Ebola response roadmap situation report. Geneva: World Health Organization; 2014 Nov 12 [cited 2016 Oct 12]. Available from: http://apps.who.int/iris/bitstream/10665/141468/1/roadmapsitrep_12Nov2014_eng.pdf.

10. World Health Organization. Ebola situation report—17 June 2015. Geneva: World Health Organization; 2015 Jun 17 [cited 2016 Oct 12]. Available from: http://apps.who.int/ebola/current-situation/ebola-situation-report-17-june-2015.

11. WHO Ebola Response Team. Ebola virus disease in West Africa—the first 9 months of the epidemic and forward projections. N Engl J Med. 2014;371(16):1481–95. doi: 10.1056/NEJMoa1411100 25244186; PubMed Central PMCID: PMC4235004.

12. WHO Ebola Response Team. West African Ebola epidemic after one year—slowing but not yet under control. N Engl J Med. 2015;372(6):584–7. doi: 10.1056/NEJMc1414992 25539446.

13. WHO Ebola Response Team. Ebola virus disease among children in West Africa. N Engl J Med. 2015;372(13):1274–7. doi: 10.1056/NEJMc1415318 25806936

14. WHO Ebola Response Team. Ebola virus disease among male and female persons in West Africa. N Engl J Med. 2016;2016(374):96–8.

15. National Institute of Standards and Technology. Secure Hash Standard (SHS). FIPS 180–4. Gaithersburg (Maryland): National Institute of Standards and Technology; 2015 Aug [cited 2016 Oct 20]. Available from: http://csrc.nist.gov/publications/fips/fips180-4/fips-180-4.pdf.

16. World Health Organization. Case definition recommendations for Ebola or Marburg virus diseases. Geneva: World Health Organization; 2014 Aug 9 [cited 2016 Oct 12]. Available from: http://www.who.int/csr/resources/publications/ebola/ebola-case-definition-contact-en.pdf.

17. Burnham KP, Anderson DR. Model selection and multimodel inference: a practical information-theoretic approach. 2nd ed. New York: Springer-Verlag; 2002.

18. Fraser C. Estimating individual and household reproduction numbers in an emerging epidemic. PLoS ONE. 2007;2(8):e758. doi: 10.1371/journal.pone.0000758 17712406; PubMed Central PMCID: PMC1950082.

19. Cori A, Ferguson NM, Fraser C, Cauchemez S. A new framework and software to estimate time-varying reproduction numbers during epidemics. Am J Epidemiol. 2013;178(9):1505–12. doi: 10.1093/aje/kwt133 24043437; PubMed Central PMCID: PMC3816335.

20. Ripley BD, Thompson M. Regression techniques for the detection of analytical bias. Analyst. 1987;112:377–83.

21. Therneau T. deming: Deming, Thiel-Sen and Passing-Bablock Regression. Version 1.0–1. R Project for Statistical Computing; 2014 Sep 24 [cited 2016 Oct 12]. Available from: http://CRAN.R-project.org/package=deming.

22. R Foundation. The R Project for Statistical Computing. Vienna: R Foundation; 2014 [cited 2016 Oct 20]. Available from: https://www.r-project.org/.

23. Dowell SF, Mukunu R, Ksiazek TG, Khan AS, Rollin PE, Peters CJ. Transmission of Ebola hemorrhagic fever: a study of risk factors in family members, Kikwit, Democratic Republic of the Congo, 1995. Commission de Lutte contre les Epidemies a Kikwit. J Infect Dis. 1999;179(Suppl 1):S87–91. doi: 10.1086/514284 9988169.

24. Wamala JF, Lukwago L, Malimbo M, Nguku P, Yoti Z, Musenero M, et al. Ebola hemorrhagic fever associated with novel virus strain, Uganda, 2007–2008. Emerg Infect Dis. 2010;16(7):1087–92. doi: 10.3201/eid1607.091525 20587179; PubMed Central PMCID: PMC3321896.

25. Francesconi P, Yoti Z, Declich S, Onek PA, Fabiani M, Olango J, et al. Ebola hemorrhagic fever transmission and risk factors of contacts, Uganda. Emerg Infect Dis. 2003;9(11):1430–7. doi: 10.3201/eid0911.030339 14718087; PubMed Central PMCID: PMC3035551.

26. Lloyd-Smith JO, Schreiber SJ, Kopp PE, Getz WM. Superspreading and the effect of individual variation on disease emergence. Nature. 2005;438(7066):355–9. doi: 10.1038/nature04153 16292310.

27. Pathmanathan I, O’Connor KA, Adams ML, Rao CY, Kilmarx PH, Park BJ, et al. Rapid assessment of Ebola infection prevention and control needs—six districts, Sierra Leone, October 2014. MMWR Morb Mortal Wkly Rep. 2014;63(49):1172–4. 25503922

28. World Health Organization. Ebola outbreak 2014–2015. Geneva: World Health Organization; 2016 [cited 2016 Oct 12]. Available from: http://www.who.int/csr/disease/ebola/en/.

29. Faye O, Boelle PY, Heleze E, Faye O, Loucoubar C, Magassouba N, et al. Chains of transmission and control of Ebola virus disease in Conakry, Guinea, in 2014: an observational study. Lancet Infect Dis. 2015;15(3):320–6. doi: 10.1016/S1473-3099(14)71075-8 25619149.

30. Nyenswah T, Fallah M, Calvert G, Duwor S, Hamilton E, Mokashi V, et al. Cluster of Ebola virus disease, Bong and Montserrado Counties, Liberia. Emerg Infect Dis. 2015;21(7):1253–6. doi: 10.3201/eid2107.150511 26079309

31. Nyenswah T, Fallah M, Sieh S, Kollie K, Badio M, Gray A, et al. Controlling the last known cluster of Ebola virus disease—Liberia, January–February 2015. MMWR Morb Mortal Wkly Rep. 2015:64:500–4. 25974635

32. Dietz P, Jambai A, Paweska JT, Yoti Z, Ksaizek TG. Epidemiology and risk factors for Ebola virus infection in Sierra Leone—May 23, 2014–January 31, 2015. Clin Infect Dis. 2015;61(11):1648–54. doi: 10.1093/cid/civ568 26179011

33. Lindblade KA, Kateh F, Nagbe TK, Neatherlin JC, Pillai SK, Attfield KR, et al. Decreased Ebola transmission after rapid response to outbreaks in remote areas, Liberia, 2014. Emerg Infect Dis. 2015;21(10):1800–7. doi: 10.3201/eid2110.150912 26402477

34. Lamunu M, Lutwama JJ, Kamugisha J, Opio A, Nambooze J, Ndayimirije N, et al. Containing hemorrhagic fever epidemic, the ebola experience in Uganda (October 2000–January 2001). 10th International Congress on Infectious Diseases; 2002 Mar 11–14; Singapore.

35. Roels TH, Bloom AS, Buffington J, Muhungu GL, Mac Kenzie WR, Khan AS, et al. Ebola hemorrhagic fever, Kikwit, Democratic Republic of the Congo, 1995: risk factors for patients without a reported exposure. J Infect Dis. 1999;179(Suppl 1):S92–7. doi: 10.1086/514286 9988170.

36. Fitzpatrick G, Vogt F, Gbabai OBM, Decroo T, Keane M, De Clerck H, et al. The contribution of Ebola viral load at admission and other patient characteristics to mortality in a Médecins Sans Frontières (MSF) Ebola Case Management Centre (CMC), Kailahun, Sierra Leone, June–October, 2014. J Infect Dis. 2015;212(11):1752–8. doi: 10.1093/infdis/jiv304 26002981

37. Fasina F, Shittu A, Lazarus D, Tomori O, Simonsen L, Viboud C, et al. Transmission dynamics and control of Ebola virus disease outbreak in Nigeria, July to September 2014. Euro Surveill. 2014;19(40):20920. 25323076

38. Khan AS, Tshioko FK, Heymann DL, Le Guenno B, Nabeth P, Kerstiëns B, et al. The reemergence of Ebola hemorrhagic fever, Democratic Republic of the Congo, 1995. J Infect Dis. 1999;179(Suppl 1):S76–86.

39. Cori A, Boelle PY, Thomas G, Leung GM, Valleron AJ. Temporal variability and social heterogeneity in disease transmission: the case of SARS in Hong Kong. PLoS Comput Biol. 2009;5(8):e1000471. doi: 10.1371/journal.pcbi.1000471 19696879; PubMed Central PMCID: PMC2717369.

40. Li Y, Yu IT, Xu P, Lee JH, Wong TW, Ooi PL, et al. Predicting super spreading events during the 2003 severe acute respiratory syndrome epidemics in Hong Kong and Singapore. Am J Epidemiol. 2004;160(8):719–28. doi: 10.1093/aje/kwh273 15466494.

41. Stein RA. Super-spreaders in infectious diseases. Int J Infect Dis. 2011;15(8):e510–3. doi: 10.1016/j.ijid.2010.06.020 21737332.

42. Gostin LO, Lucey D. Middle East respiratory syndrome: a global health challenge. JAMA. 2015;314(8):771–2. doi: 10.1001/jama.2015.7646 26084030

43. Watts DJ, Muhamad R, Medina DC, Dodds PS. Multiscale, resurgent epidemics in a hierarchical metapopulation model. Proc Natl Acad Sci U S A. 2005;102(32):11157–62. doi: 10.1073/pnas.0501226102 16055564; PubMed Central PMCID: PMC1183543.

44. Salathe M, Jones JH. Dynamics and control of diseases in networks with community structure. PLoS Comput Biol. 2010;6(4):e1000736. doi: 10.1371/journal.pcbi.1000736 20386735; PubMed Central PMCID: PMC2851561.

45. Ebola ça Suffit Ring Vaccination Trial Consortium. The ring vaccination trial: a novel cluster randomized controlled trial design to evaluate vaccine efficacy and effectiveness during outbreaks, with special reference to Ebola. BMJ. 2015;351:h3740. doi: 10.1136/bmj.h3740 26215666

46. Victory KR, Coronado F, Ifono SO, Soropogui T, Dahl BA. Ebola transmission linked to a single traditional funeral ceremony—Kissidougou, Guinea, December, 2014–January 2015. MMWR Morb Mortal Wkly Rep. 2015;64(14):386–8. 25879897

47. Gulland A. Liberia confirms Ebola case two months after being declared free of the disease. BMJ. 2015;350:h3620. doi: 10.1136/bmj.h3620 26138714