Association of vitamin D with risk of type 2 diabetes: A Mendelian randomisation study in European and Chinese adults
Robert Clarke and colleagues, using a Mendelian Randomisation approach, reveal a link between higher levels of vitamin D and type 2 diabetes prevention, based on data from 2 large cohorts.
Vyšlo v časopise:
Association of vitamin D with risk of type 2 diabetes: A Mendelian randomisation study in European and Chinese adults. PLoS Med 15(5): e32767. doi:10.1371/journal.pmed.1002566
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pmed.1002566
Souhrn
Robert Clarke and colleagues, using a Mendelian Randomisation approach, reveal a link between higher levels of vitamin D and type 2 diabetes prevention, based on data from 2 large cohorts.
Zdroje
1. Forouhi NG, Wareham NJ. Epidemiology of diabetes. Medicine. 2014;42:698–702. doi: 10.1016/j.mpmed.2014.09.007 25568613
2. Holick MF. Vitamin D deficiency. N Engl J Med. 2007; 357:266–81. doi: 10.1056/NEJMra070553 17634462
3. Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr. 2004;80:1678S–88S. 15585788
4. Lu L, Yu Z, Pan A, Hu FB, Franco OH, Li H, et al. Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals. Diabetes Care. 2009;32:1278–83. doi: 10.2337/dc09-0209 19366976
5. Ye Z, Sharp SJ, Burgess S, Scott RA, Imamura F, InterAct Consortium, et al. Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a Mendelian randomisation study. Lancet Diabetes Endocrinol. 2015;3:35–42. doi: 10.1016/S2213-8587(14)70184-6 25281353
6. Song Y, Wang L, Pittas AG, Del Gobbo LC, Zhang C, Manson JE, et al. Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies. Diabetes Care. 2013;36:1422–8. doi: 10.2337/dc12-0962 23613602
7. Afzal S, Bojesen SE, Nordestgaard BG. Low 25-hydroxyvitamin D and risk of type 2 diabetes: a prospective cohort study and metaanalysis. Clin Chem. 2013;59:381–91. doi: 10.1373/clinchem.2012.193003 23232064
8. Avenell A, Cook JA, MacLennan GS, McPherson GC. Vitamin D supplementation and type 2 diabetes: a substudy of a randomised placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438). Age Ageing. 2009;38:606–9. doi: 10.1093/ageing/afp109 19617604
9. Nikooyeh B, Neyestani TR, Farvid M, Alavi-Majd H, Houshiarrad A, Kalayi A, et al. Daily consumption of vitamin D- or vitamin D plus calcium-fortified yogurt drink improved glycemic control in patients with type 2 diabetes: a randomized clinical trial. Am J Clin Nutr. 2011;93:764–71. doi: 10.3945/ajcn.110.007336 21289226
10. Mitri J, Dawson-Hughes B, Hu FB, Pittas AG. Effects of vitamin D and calcium supplementation on pancreatic beta cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial. Am J Clin Nutr. 2011;94:486–94. doi: 10.3945/ajcn.111.011684 21715514
11. de Boer IH, Tinker LF, Connelly S, Curb JD, Howard BV, Kestenbaum B, et al. Calcium plus vitamin D supplementation and the risk of incident diabetes in the Women’s Health Initiative. Diabetes Care. 2008;31:701–7. doi: 10.2337/dc07-1829 18235052
12. Jorde R, Sneve M, Torjesen P, Figenschau Y. No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D3 for 1 year. J Intern Med. 2010;267:462–72. doi: 10.1111/j.1365-2796.2009.02181.x 20141565
13. Berry DJ, Vimaleswaran KS, Whittaker JC, Hingorani AD, Hyponen E. Evaluation of genetic instruments for Mendelian randomization studies. PLoS ONE. 2012;7:e37465.
14. Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Berry D, et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet. 2010;376:180–8. doi: 10.1016/S0140-6736(10)60588-0 20541252
15. Ahn J, Yu K, Stolzenberg-Solomon R, Simon KC, McCullough ML, Gallicchio L, et al. Genome-wide association study of circulating vitamin D levels. Human Mol Genet. 2010;19:2739–45.
16. Powe CE, Evans MK, Wenger J, Zonderman AB, Berg AH, Nalls M, et al. Vitamin D-binding protein and vitamin D status of black Americans and white Americans. N Engl J Med. 2013;369:1991–2000. doi: 10.1056/NEJMoa1306357 24256378
17. Schoenmakers I, Jones KS. Letter to the editor: the effect of genetic factors on the response to vitamin D supplementation may be mediated by vitamin D-binding protein concentrations. J Clin Endocrinol Metab. 2017;102:2562–3. doi: 10.1210/jc.2017-00666 28899076
18. Jones G, Prosser DE, Kaufmann M. 25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): its important role in the degradation of vitamin D. Arch Biochem Biophys. 2012;523:9–18. doi: 10.1016/j.abb.2011.11.003 22100522
19. Buijsse B, Boeing H, Hirche F, Weikert C, Schulze MB, Gottschald M, et al. Plasma 25-hydroxyvitamin D and its genetic determinants in relation to incident type 2 diabetes: a prospective case-cohort study. Eur J Epidemiol. 2013;28:743–52. doi: 10.1007/s10654-013-9844-5 24002339
20. Jorde R, Schirmer H, Wilsgaard T, Joakimsen RM, Mathiesen EB, Njølstad I, et al. Polymorphisms related to the serum 25-hydroxyvitamin D level and risk of myocardial infarction, diabetes, cancer and mortality: the Tromsø Study. PLoS ONE. 2012;7:e37295. doi: 10.1371/journal.pone.0037295 22649517
21. Afzal S, Brøndum-Jacobsen P, Bojesen SE, Nordestgaard BG. Vitamin D concentration, obesity, and risk of diabetes: a Mendelian randomisation study. Lancet Diabetes Endocrinol. 2015;3:35–42.
22. Forouhi NG, Ye Z, Rickard AP, Khaw KT, Luben R, Langenberg C, et al. The association and causal inference between circulating 25-hydroxy vitamin D concentration and the risk of type 2 diabetes. Diabetologia. 2011;55:2173–82.
23. Scott RA, Scott LJ, Mägi R, Marullo L, Gaulton KJ, Kaakinen M, et al. An expanded genome-wide association study of type 2 diabetes in Europeans. Diabetes. 2017;66:2888–902. doi: 10.2337/db16-1253 28566273
24. Chen Z, Chen J, Collins R, Guo Y, Peto R, Wu F, et al. China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up. Int J Epidemiol. 2011;40:1652–66. doi: 10.1093/ije/dyr120 22158673
25. Plummer M. Improved estimates of floating absolute risk. Stat Med. 2004;15;23:93–104. doi: 10.1002/sim.1485 14695642
26. Burgess S, Thompson S. Use of allele scores as instrumental variables for Mendelian randomization. Int J Epidemiol. 2013;42:1134–44. doi: 10.1093/ije/dyt093 24062299
27. Yavorska OO, Burgess S. Mendelian randomization: an R package for performing Mendelian randomization analyses using summarized data. Int J Epidemiol. 2017;46:1734–9. doi: 10.1093/ije/dyx034 28398548
28. Otterbein LR, Cosio C, Graceffa P, Dominguez R. Crystal structures of the vitamin D-binding protein and its complex with actin: structural basis of the actin-scavenger system. Proc Natl Acad Sci U S A. 2002;99:8003–8. doi: 10.1073/pnas.122126299 12048248
29. Zhang J, Kew RR. Identification of a region in the vitamin D-binding protein that mediates its C5a chemotactic cofactor function. J Biol Chem. 2004;279:53282–7. doi: 10.1074/jbc.M411462200 15485893
30. Vimaleswaran KS, Cavadino A, Berry DJ, LifeLines Cohort Study investigators, Jorde R, Dieffenbach AK, et al. Association of vitamin D status with arterial blood pressure and hypertension risk: a Mendelian randomisation study. Lancet Diabetes Endocrinol. 2014:2:719–29. doi: 10.1016/S2213-8587(14)70113-5 24974252
31. Halban PA, Polonsky KS, Bowden DW, Hawkins MA, Ling C, Mather KJ, et al. Beta-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. J Clin Endocrinol Metab. 2014;99:1983–92. doi: 10.1210/jc.2014-1425 24712577
32. Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab. 2007;92:2017–29. doi: 10.1210/jc.2007-0298 17389701
33. Clark SA, Stumpf WE, Sar M. Effect of 1,25 dihydroxyvitamin D3 on insulin secretion. Diabetes. 1981;30:382–6. 7014306
34. Mäkinen M, Simell V, Mykkänen J, Ilonen J, Veijola R, Hyöty H, et al. An increase in serum 25-hydroxyvitamin D concentrations preceded a plateau in type 1 diabetes incidence in Finnish children. J Clin Endocrinol Metab. 2014;99:e2353–6. doi: 10.1210/jc.2014-1455 25062454
35. Hin H, Tomson J, Newman C, Kurien R, Lay M, Cox J, et al. Optimum dose of vitamin D for disease prevention in older people: BEST-D trial of vitamin D in primary care. Osteoporosis Int. 2017;28:841–51.
36. Pittas AG, Dawson-Hughes B, Sheehan PR, Rosen CJ, Ware JH, Knowler WC, et al. Rationale and design of the vitamin D and type 2 diabetes (D2d) study: a diabetes prevention trial. Diabetes Care. 2014;37:3227–34. doi: 10.2337/dc14-1005 25205139
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