Inhibítory aromatázy v liečbe karcinómu prsníka: prehľad a možné prínosy u žien pred menopauzou

Nová generácia inhibítorov aromatázy predstavuje v súčasnosti prvú voľbu v endokrinnej liečbe pokročilého karcinómu prsníka u postmenopauzálnych pacientiek. Tieto farmaká sú rovnako účinné aj v adjuvantnej a neoadjuvantnej liečbe, výsledky niekoľkých prebiehajúcich štúdií môžu poukázať na ich úlohu v chemoprevencii rakoviny prsníka. Okrem toho sú potrebné dlhodobejšie štúdie, ktoré by dôsledne objasnili nežiaduce účinky inhibítorov aromatázy na ľudský organizmus. Účinnosť a bezpečnosť samostatne aplikovaných inhibítorov aromatázy u premenopauzálnych pacientiek s rakovinou prsníka je neznáma, v tejto oblasti bude potrebný ďalší výskum. Kombinované podávanie agonistov hormónu uvoľňujúceho luteinizačný hormón s inhibítormi aromatázy rozširuje využitie endokrinnej liečby rakoviny prsníka u premenopauzálnych žien či už s metastatickou alebo včasnou formou ochorenia. Výsledky našich štúdií chemoprevencie mamárnej karcinogenézy u samíc potkanov poukázali na potenciálnu výhodnosť aplikácie inhibítorov aromatázy – anastrozolu a letrozolu u premenopauzálnych žien postihnutých rakovinou prsníka.

Kľúčové slová:
inhibítory aromatázy – rakovina prsníka – premenopauzálne ženy – agonisti hormónu uvoľňujúceho luteinizačný hormón

Autoři: P. Kubatkaihash2 ^{1,2 1,2}; K. Kajo ³; N. Stollárová ²; B. Bojková ⁴; M. Kassayová ⁴; P. Orendáš ⁴
Působiště autorů: Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic ¹; Department of Biology and Ecology, Faculty of Education, Catholic University, Ružomberok, Slovak Republic ²; Department of Pathology, Slovak Medical University and St. Elisabeth Oncology Institute, Bratislava, and BB Biocyt, Diagnostic Centre, Ltd., Banská Bystrica, Slovak Republic ³; Department of Animal Physiology, Institute of Biological and Ecological Sciences, Science Faculty, P. J. Šafárik University, Košice, Slovak Republic ⁴
Vyšlo v časopise: Prakt Gyn 2011; 15(3-4): 174-180
Kategorie: Přehledová práce

Souhrn

Kľúčové slová:
inhibítory aromatázy – rakovina prsníka – premenopauzálne ženy – agonisti hormónu uvoľňujúceho luteinizačný hormón

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