Indapamide is not only a diuretic

Česká verzia

Authors: Špinarová L. ¹; Špinar J. ²; Vítovec J. ¹
Authors place of work: I. interní kardioangiologická klinika LF MU a FN u sv. Anny v Brně ¹; Ústav lékařské fyziologie, LF MU Brno ²
Published in the journal: Kardiol Rev Int Med 2019, 21(4): 209-212

Summary

Indapamide is not only a simple diuretic, but also a vasodilating substance which acts through the prostaglandines and increases calcium inflow into the myocytes. It is metabolic neutral and does not influence the level of glucose or lipids. It decreases the blood pressure and in combination with perindopril also has mortality evidence from the clinical trials HYVET and ADVANCE. Cerebroprotective data are in the PROGRESS trial. Two recent meta-analyses show data about the effect on regression of left ventricular hypertrophy, which is more pronounced than with hydrochlorothiazide. The decrease of blood pressure is a basic but not the only criterion for the treatment of hypertension. If we decide on the usage of diuretics, indapamide should be preferred.

Keywords:

hypertension – indapamide – left ventricular hypertrophy – patient prognosis

Zdroje

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