Nitrendipine – a modern calcium channel blocker

Česká verzia

Authors: Špinar J. ¹; Špinarová L. ²; Vítovec J. ²
Authors place of work: Ústav fyziologie, LF MU Brno ¹; Interní kardioangiologická klinika LF MU a FN u sv. Anny v Brně ²
Published in the journal: Kardiol Rev Int Med 2019, 21(4): 214-219

Summary

Calcium channel bockers belong among the five basic antihypertensive drug classes. They are divided into dihydropyridines, phenylalkylamines and benzothiazepines. They are used in monotherapy or in combination therapy, mainly with renin angiotensin aldosterone blockers, but also with diuretics or beta blockers. The most frequently used are dihydropyridines of the second generation; a representative of these is, for example nitrendipine. Nitrendipine was tested in a large clinical trial, SYST EUR in patients over 60 years of age and with isolated systolic hypertension; in comparison with hydrochlorothiazide, nitrendpine was more effective in lowering blood pressure but also for cardiovascular events, especially cerebrovascular events and cardiac events, including angina pectoris. The recommended dose of nitrendipine is 10–20 mg once daily.

Keywords:

hypertension – dihydropyridines – nitrendipine

Zdroje

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