Central Neurocytoma: Case Report and Review of the Literature

Česká verzia

Authors: V. Beneš III. ¹; P. Buchvald ¹; M. Kaiser ¹; J. Mikuláštík ²; P. Suchomel ¹
Authors place of work: Neurochirurgické oddělení, Krajská Nemocnice Liberec ¹; Oddělení patologie, Krajská Nemocnice Liberec ²
Published in the journal: Cesk Slov Neurol N 2007; 70/103(6): 697-701
Category: Case Report

Poděkování: Autoři děkují za druhé čtení histologie a provedení MIB-1 prof. MUDr. S. Němečkovi, DrSc.

Summary

Central neurocytoma is a rare brain tumor predominantly encountered among young patients typically localized close to the foramen of Monro and septum pellucidum. In the absence of atypical histology, the prognosis after complete resection is usually excellent. We present a case of a 30 years old man with mild hemiparesis which led to the diagnosis of a tumor of the third and both lateral ventricles. The patient underwent partial tumor resection in two surgeries. Histologically the tumor resembled oligodendroglioma, however the cells were imunoreactive for synaptophysin. MIB-1 proliferative index was higher than 3%. On the basis of these findings, diagnosis of atypical central neurocytoma was made. The patient is symptom-free 18 months after the first surgery, residual tumor is closely observed. At the first sign of progression the patient will recieve radiotherapy. Apart from the case report we review the literature and discuss clinical and therapeutical aspects of this tumor.

Key words:
brain neoplasm – neurocytoma – intraventricular tumor – radiation therapy – synaptophysin

Zdroje

1. Rades D, Schild E. Treatment recommendations for the various subgroups of neurocytoma. J Neurooncol 2006; 77: 305-309.

2. Hassoun J, Gambarelli D, Grisoli F, Pellet W, Salamon G, Pellissier JF et al. Central neurocytoma. An electron-microscopic study of two cases. Acta Neuropathol (Berl) 1982; 56: 151-156.

3. Bertalanffy A, Roessler K, Koperek O, Gelpi E, Prayer D, Knosp E. Recurrent central neurocytomas. Cancer 2005; 104: 135-142.

4. Metcalf C, Mele EM, McAllister I. Neurocytoma of the retina. Br J Ophthalmol 1993; 77: 382-384.

5. Kowalski RJ, Prayson RA, Lee JH. Skull base neruocytoma: Case report and review of the literature of extraventricular neurocytomas. Skull Base 2002; 12: 59-65.

6. Enam SA, Rosenblum ML, Ho K-L. Neurocytoma in the cerebellum: Case report. J Neurosurg 1997; 87: 100-102.

7. Swinson BM, Friedman WA, Yachnis AT. Pontine atypical neurocytoma: Case report. Neurosurgery 2006; 58: 990-991.

8. Tatter SB, Borges LF, Louis DN. Central neurocytomas of the cervical spinal cord: Report of two cases. J Neurosurg 1994; 81: 288-293.

9. Friedrichs N, Vorreuther R, Fischer H-P, Wiestler OD, Buettner R. Neurocytoma arising in the pelvis. Virchows Arch 2003; 443: 217-9.

10. Hirschowitz L, Ansari A, Cahill DJ, Bamford DS, Love S. Central neurocytoma arising within a mature cystic teratoma of the ovary. Int J Gynecol Pathol 1997; 16: 176-179.

11. Figarella-Branger D, Söylemezoglu F, Kleihues P, Hassoun J. Central neurocytoma. In: Kleihues P, Cavenee WK (eds). Pathology and genetics of tumors of the nervous system. Lyon: IARCPress 2000: 107-109.

12. Schild SE, Scheithauer BW, Haddock MG, Schiff D, Burger PC, Wong WW et al. Central neurocytomas. Cancer 1997; 79: 790-795.

13. Yaşargil MG, von Ammon K, von Deimling A, Valavanis A, Wichmann W, Wiestler OD. Central neurocytoma: histopathological variants and therapeutic approaches J Neurosurg 1992; 76: 32-37.

14. Cobery ST, Noren G, Friehs GM, Chougule P, Zheng Z, Epstein MH et al. Gamma knife surgery for the treatment of central neurocytoma. J Neurosurg 2001; 94: 327-330.

15. Eng DY, DeMonte F, Ginsberg L, Fuller GN, Jaeckle K. Craniospinal dissemination of central neurocytoma. Report of two cases. J Neurosurg 1997; 86: 547-552.

16. Kulkarni V, Rajshekhar V, Haran RP, Chandi SM. Long-term outcome in patients with central neurocytoma following stereotactic biopsy and radiation therapy. Br J Neurosurg 2002; 16: 126-132.

17. Kim DG, Kim JS, Chi JG, Park SH, Jung H-W, Choi KS et al. Central neurocytoma: proliferative potential and biological behavior. J Neurosurg 1996; 84: 742-747.

18. Valdueza JM, Westphal M, Vortmeyer A, Muller D, Padberg B, Herrmann HD. Central neurocytoma: clinical, immunohistologic, and biologic findings of a human neuroglial progenitor tumor. Surg Neurol 1996; 45: 49-56.

19. Sim FJ, Keyoung HM, Goldman JE, Kim DK, Jung H-W, Roy NS et al. Neurocytoma is a tumor of adult neuronal progenitor cells. J Neurosci 2006; 26: 12544-12555.

20. Yin X-L, Pang JC-S, Hui AB-Y, Phil M, Ng H-K. Detection of chromosomal imbalances in central neurocytomas by using comparative genomic hybridization. J Neurosurg 2000; 93: 77-81.

21. Zhang D, Wen L, Henning TD, Feng X-Y, Zhang Y-L, Zou L-G et at. Central neurocytoma: clinical, pathological and neuroradiological findings. Clin Radiol 2006; 61: 348-357.

22. Balko MG, Schultz DL. Sudden death due to a central neurocytoma. Am J Forensic Med Pathol 1999; 20: 180-183.

23. Ashkan K, Casey AT, D’Arrigo C, Harkness WF, Thomas DG. Benign central neurocytoma. A double misnomer? Cancer 2000; 89: 1111-20.

24. Rades D, Fehlauer F. Treatment options for central neurocytoma. Neurology 2002; 59: 1268-1270.

25. Rades D, Fehlauer F, Lamszus K, Schild SE, Hagel C, Westphal M et al. Well-differentiated neurocytoma: What is the best available treatment? Neuro-Oncol 2005; 7: 77-83.

26. Rades D, Schild SE. Value of postoperative stereotactic radiosurgery and conventional radiotherapy for incompletely resected typical neurocytomas. Cancer 2006; 106: 1140-1143.

27. Anderson RC, Elder JB, Parsa AT, Issacson SR, Sisti MB. Radiosurgery for the treatment of recurrent central neurocytomas. Neurosurgery 2001; 48: 1231-1238.

28. Martín JM, Katati M, López E, Bullejos JA, Arregui G, Busquier H et al. Linear accelerator radiosurgery in treatment of central neurocytomas. Acta Neurochir (Wien) 2003; 145: 749-754.

29. Armstrong CL, Gyato K, Awadalla AW, Lustig R, Tochner ZA. A critical review of the clinical effects of therapeutic irradiation damage to the brain: the roots of controversy. Neuropsychol Rev 2004; 14: 65-86.

30. Ron E, Modan B, Boice JD Jr, Alfandary E, Stovall M, Chetrit A et al. Tumors of the brain and nervous system after radiotherapy in childhood. N Engl J Med 1988; 319: 1033-1039.

31. Von Koch CS, Schmidt MH, Uyehara-Lock JH, Berger MS, Chang SM. The role of PCV chemotherapy in the treatment of central neurocytoma: Illustration of a case and review of the literature. Surg Neurol 2003; 60: 560-565.