Landau- Kleffner Syndrome and Long‑term Adrenocorticotropic Hormone Therapy – a Case Report

Česká verzia

Authors: L. Švecová; P. Sýkora; M. Kolníková
Authors place of work: Klinika detskej neurológie LF UK a DFNsP Bratislava
Published in the journal: Cesk Slov Neurol N 2015; 78/111(1): 93-97
Category: Case Report
doi: https://doi.org/10.14735/amcsnn201593

Summary

The electrical status epilepticus in slow sleep (ESES) is characterised by specific EEG pattern of paroxysmal activity significantly activated during slow sleep. There are more clinical variants associated with an EEG pattern of ESES (for example Landau-Kleffner syndrome, continuous spike and wave syndrome – CSWS, benign childhood epilepsy with centro-temporal spikes, atypical benign partial epilepsy of childhood, myoclonic-astatic epilepsy). Therapy of ESES syndrome is not limited just to seizure control but it should be focused on controlling neuropsychological outcome through improved continuous epileptiform activity. Even though the epileptic seizures and the EEG pattern of ESES are age-related, many children have persisting cognitive and language disturbances. Early diagnosis and effective treatment are necessary for better outcome in these patients. In our case report we present the good effect of long-term adrenocorticotropic hormone therapy.

Key words:
electrical status epilepticus in slow wave sleep – cognitive deterioration – adrenocorticotropic hormone

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

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