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Analysis of medication administration in relation to food and beverages in inpatients


Authors: Ondřej Tesař 1;  Josef Malý 1;  Lucie Malečová 1;  Kateřina Malá-Ládová 1;  Martin Doseděl 1;  Iva Brabcová 2;  Martin Červený 2;  Radka Prokešová 3;  Hana Hajduchová 2;  Ivana Chloubová 2;  Valérie Tóthová 2;  Jiří Vlček 1
Authors place of work: Farmaceutická fakulta UK v Hradci Králové Katedra sociální a klinické farmacie 1;  Ústav ošetřovatelství, porodní asistence a neodkladné péče Zdravotně sociální fakulta JU, České Budějovice 2;  Ústav humanitních studií v pomáhajících profesích Zdravotně sociální fakulta JU, České Budějovice 3
Published in the journal: Čes. slov. Farm., 2023; 72, 304-311
Category: Original Articles
doi: https://doi.org/10.5817/CSF2023-6-303

Summary

Proper medication administration in relation to beverage or food is one of the essential tools to achieve the pharmacotherapy goals. It is not known whether this is also considered in the care of inpatients. The aim of this study was to describe and analyse the current practice of medication administration in relation to food and beverages to patients hospitalized in four hospitals in the Czech Republic.

This study was conducted based on the results of the first phase of a prospective observation study focused on the safety of medication administration performed by nurses. All data, including the timing of medication administration in relation to food and the data on beverages used, were obtained by the method of direct observation. The team of observersaccompanied the nurse during medication administration. The appropriateness of the medication administration in relationto food/beverages was assessed according to the summary of product characteristics and the published literature.

In total, the administration of 5718 oral medications and 198 insulins were analysed. Unproper food timing wasobserved in 15.7% of oral medication administrations and 26.8% of insulin administrations. The highest number ofunproper food timing occurred in the proton pump inhibitors, antihypertensives, and prokinetics. Tea (63.4%) was the most used beverage. Errors with clinically serious impact have been observed in some groups of drugs. The necessity of a systemic approach in management of medication administration is required including interdisciplinary cooperation.

Keywords:

nurse – medication error – hospital – food-drug interaction – medication administration


Zdroje
  1. Vlček J., Bártlová S., Brabcová I., Doseděl M., Hajduchová H., Kuběna A., Malý J., Tóthová V., Vosátka J. Minimalizace rizik ateorie tří pilířů u léčiv zvyšující riziko pádů. Klin. Farmakol. Farm. 2019; 33, 30–34.
  2. Schmidt L. E., Dalhoff K. Food-drug interactions. Drugs 2002; 62, 1481–1502.
  3. Bushra R., Aslam N., Khan A. Y. Food-drug interactions. Oman Med. J. 2011; 26. 77–83.
  4. Deng J., Zhu X., Chen Z., Fan Ch. H., Kwan H. S., Wong Ch. H., Shek K. Y., Zuo Z, Lam T. N. A Review of Food-Drug Interactions on Oral Drug Absorption. Drugs 2017; 77, 1833–1855.
  5. Gauthier I., Malone M., Lesar T. S., Aronovitch S. Comparison of programs for preventing drug–nutrient interactions in hospitalized patients. Am. J. Health-Syst. Pharm. 1997; 54, 405–411.
  6. Ochoa D., Román M., Cabaleiro T., Saiz-Rodríguez M., Mejía G., Abad-Santos F. Effect of food on the pharmacokinetics of omeprazole, pantoprazole and rabeprazole. BMC Pharmacol. Toxicol. 2020; 21, 54.
  7. Wiesner A., Zwolińska-Wcisło M., Paśko P. Effect of Food and Dosing Regimen on Safety and Efficacy of Proton Pump Inhibitors Therapy-A Literature Review. Int. J. Environ. Res. Public Health 2021; 18, 3527.
  8. Tesař O., Měrková V., Doseděl M., Malý J. Potrava jako důležitá součást maximalizace účinku a minimalizace rizik farmakoterapie – absorpce a gastrointestinální tolerance. Klin. Farmakol. Farm. 2020; 34, 108–115.
  9. Waghray A., Waghray N., Perzynski A. T., Votruba M., Wolfe M. M. Optimal Omeprazole Dosing and Symptom Control: A Randomized Controlled Trial (OSCAR Trial). Dig. Dis. Sci. 2019; 64, 158–166.
  10. Metoclopramide: Drug information. In: Lexicomp Online (přístup 18. 4. 2023), Lexicomp, Inc. 1978–2023.
  11. Food interaction checker. Drugbank Online (přístup 18. 4. 2023). Dostupné na: https://go.drugbank.com/food-interaction-checker
  12. Domperidone: Drug information. In: Lexicomp Online (přístup 18. 4. 2023), Lexicomp, Inc. 1978–2023.
  13. Motilium. Souhrn údajů o léčivém přípravku (datum revize: 17. 8. 2021). Dostupné na: https://prehledy.sukl.cz/ prehled_leciv.html#/
  14. Kinito. Souhrn údajů o léčivém přípravku (datum revize: 7. 7. 2021). Dostupné na: https://prehledy.sukl.cz/ prehled_leciv.html#/
  15. Geer M., Potter D. M., Ulrich H. Alternative schedules of levothyroxine administration. Am. J. Health. Syst. Pharm. 2015; 72, 373–377.
  16. Ased S., Wells J., Morrow L. E., Malesker M. A. Clinically Significant Food-Drug Interactions. Consult. Pharm. 2018; 33, 649–657.
  17. Koziolek M., Alcaro S., Augustijns P., Basit A. W., Grimm M., Hens B., Hoad C. L., Jedamzik P., Madla C. M., Maliepaard M.,Marciani L., Maruca A., Parrott N., Pávek P., Porter C. J. H., Reppas C., van Riet-Nales D., Rubbens J., Statelova M.,Trevaskis N. L., Valentová K., Vertzoni M., Čepo D. V., Corsetti M. The mechanisms of pharmacokinetic food-drug interactions – Aperspective from the UNGAP group. Eur. J. Pharm. Sci. 2019; 134, 31–59.
  18. Levothyroxine: Drug information. In: Lexicomp Online (přístup 4. 3. 2023), Lexicomp, Inc. 1978–2023.
  19. Skelin M., Lucijanić T., Liberati-Čizmek A. M., Klobučar S. M., Lucijanić M., Jakupović L., Bakula M., Lončar J. V., Marušić S., Matić T., Romić Ž., Dumić J, Rahelić D. Effect of timing of levothyroxine administration on the treatment of hypothyroidism: a three-period crossover randomized study. Endocrine 2018; 62, 432–439.
  20. Srivastava S., Sharma G., Rathore M., Chaturvedi A., Keswani P, Saxena G. N., Singh A., Sharma R. A Crossover Study EvaluatingEffect of Timing of Levothyroxine on Thyroid Hormone Status in Patients of Hypothyroidism. J. Assoc. Physicians India 2018; 66, 37–40.
  21. Suchopár J., Prokeš M., Suchopár Š. Levothyroxin a minimalizace rizik při zajištění optimálního klinického účinku, první část.Diabetologie, metabolismus, endokrinologie, výživa 2021; 3, 123–130.
  22. Vita R., Saraceno G., Trimarchi F., Benvenga S. A novel formulation of L-thyroxine (L-T4) reduces the problem of L-T4 malabsorption by coffee observed with traditional tablet formulations. Endocrine 2013; 43,154–160.
  23. Benvenga S., Di Bari F., Vita R. Undertreated hypothyroidism due to calcium or iron supplementation corrected by oral liquidlevothyroxine. Endocrine 2017; 56, 138–145.
  24. Syntroxine. Souhrn údajů o léčivém přípravku (datum revize: 5. 11. 2021). Dostupné na: https://prehledy.sukl.cz/ prehled_leciv.html#/
  25. Skelin M., Lucijanić T., Amidžić Klarić D., Rešić A., Bakula M., Liberati-Čizmek A. M., Gharib H., Rahelić D. Factors Affecting Gastrointestinal Absorption of Levothyroxine: A Review. Clin. Ther. 2017; 39, 378–403.
  26. Lecocq B., Funck-Brentano C., Lecocq V., Ferry A., Gardin M. E., Devissaguet M., Jaillon P. Influence of food on the pharmacokinetics of perindopril and the time course of angiotensin-converting enzyme inhibition in serum. Clin. Pharmacol. Ther. 1990; 47, 397–402.
  27. Perindopril: Drug information. In: Lexicomp Online (přístup 14. 3. 2023), Lexicomp, Inc. 1978–2023.
  28. Stampfuss J., Kubitza D., Becka M., Mueck W. The effect of food on the absorption and pharmacokinetics of rivaroxaban. Int. J. Clin. Pharmacol. Ther. 2013; 51, 549–561.
  29. Bratsos S. Pharmacokinetic Properties of Rivaroxaban in Healthy Human Subjects. Cureus 2019; 11, e5484.
  30. Aspirin: Drug information. In: Lexicomp Online (přístup 9. 3. 2023), Lexicomp, Inc. 1978–2023.
  31. Holton S., Rasmussen B., Turner J., Steele C., Ariarajah D., Hamblin S., Crowe S., Schutte S., Wynter K., Hussain IM. Nurse, midwife and patient perspectives and experiences of diabetes management in an acute inpatient setting: a mixed-methods study. BMCNurs. 2022; 21, 249.
  32. Bain A., Kavanagh S., McCarthy S., Babar Z. Assessment of Insulin-related Knowledge among Healthcare Professionals in a LargeTeaching Hospital in the United Kingdom. Pharmacy (Basel) 2019; 7, 16.
  33. Vlček J., Fialová D., Kulič F., Macek K., Rokyta R., Rudolf K., Šonka K., Tilšer I., Topinková E., Tůma I., Voříšek V., Zárubová J. Klinická farmacie I. Praha: Grada Publishing 2010.
  34. NHS. Insulin Guidelines for Adults and Children with Type 1 and Type 2 Diabetes Mellitus (v. 1.1 May 2021). Dostupné na:http://www.birminghamandsurroundsformulary.nhs.uk/
  35. Alwan D., Chipps E., Yen P. Y., Dungan K. Evaluation of the timing and coordination of prandial insulin administration in the hospital.Diabetes Res. Clin. Pract. 2017; 131: 18–32.
  36. Chlup R. Insulinová analoga – základ moderní léčby diabetu 1. i 2. typu. Interní Med. 2015; 17, 83–86.
  37. Bekersky I., Dressler D., Mekki Q. A. Effect of lowand high-fat meals on tacrolimus absorption following 5 mg single oral doses tohealthy human subjects. J. Clin. Pharmacol. 2001; 41, 176–182.
  38. Huppertz A., Bollmann J., Behnisch R., Bruckner T., Zorn M., Burhenne J., Haefeli W. E., Czock D. Differential Effect of a Continental Breakfast on Tacrolimus Formulations With Different Release Characteristics. Clin. Pharmacol. Drug Dev. 2021; 10, 899–907.
  39. Košťálová B., Dusilová-Sulková S., Guňka I, Malá-Ládová K., Malý J., Matysková-Kubišová M., Šafránek R. Světem léků po transplantaci. Hradec Králové: Tigis 2020.
  40. Tacrolimus (systemic): Drug information. In: Lexicomp Online (přístup 13. 3. 2023), Lexicomp, Inc. 1978–2023.
  41. Hurrell R., Egli I. Iron bioavailability and dietary reference values. Am. J. Clin. Nutr. 2010; 91, 1461S–1467S.
  42. Lynch S. R. The effect of calcium on iron absorption. Nutr. Res. Rev. 2000; 13, 141–158.
  43. Ferrous sulfate: Drug information. In: Lexicomp Online (přístup 6. 3. 2023), Lexicomp, Inc. 1978–2023.
  44. An G., Mukker J. K., Derendorf H., Frye R. F. Enzymeand transporter-mediated beverage-drug interactions: An update on fruit juices and green tea. J. Clin. Pharmacol. 2015; 55, 1313–1331.
  45. Cortés M., Díaz R., Verdugo S., Cabrera S., Torres-Vergara P. Pharmacokinetic interactions of fruit juices and herbalpreparations. Rev. méd. Chille 2021: 7, 1036–1046.
  46. Chen M., Zhou S. Y., Fabriaga E., Zhang P. H., Zhou Q. Food-drug interactions precipitated by fruit juices other than grapefruit juice: An update review. J. Food Drug. Anal. 2018; 26, S61–S71.
  47. Bilastine: Drug information. In: Lexicomp Online (přístup 19. 4. 2023), Lexicomp, Inc. 1978–2023.
  48. Nomani H., Moghadam A. T., Emami S. A., Mohammadpour A. H., Johnston T. P., Sahebkar A. Drug interactions of cola-containing drinks. Clin. Nutr. 2019; 38, 2545–2551.
  49. Santucci R., Levêque D., Herbrecht R. Cola
Štítky
Pharmacy Clinical pharmacology

Článok vyšiel v časopise

Czech and Slovak Pharmacy

Číslo 6

2023 Číslo 6

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