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Pernicious anemia


Authors: L. Raida
Authors place of work: Přednosta: Prof. MUDr. Karel Indrák, DrSc. ;  Hemato-onkologická klinika Lékařské fakulty Univerzity Palackého a Fakultní nemocnice Olomouc
Published in the journal: Prakt. Lék. 2008; 88(7): 380-384
Category: Various Specialization

Summary

Pernicious anemia is one of the megaloblastic anemias caused by cobalamin deficiency. However, unlike the other anemias developed due to a long-lasting cobalamin insufficient diet or consumption, this disease is absolutely specific because of its autoimmune pathogenesis. The correct diagnosis of pernicious anemia is usually determined later because of the fact that neurological and other unspecified symptoms (including possible symptoms of accompanied autoimmune disease) have frequently preceded the manifestation of anemic syndrome. It can play an important role. The changes already developed in the nervous system may have become irreversible if the diagnosis was set at the time of severe anemia development even in spite of following sufficient vitamin B12 substitution. The possible association of pernicious anemia with another autoimmune disease should never be omitted in clinical practice.

Key words:
pernicious anemia, atrophic gastritis, intrinsic factor, cobalamin, autoimmune disease, gastric carcinoma.


Zdroje

1. Ali, S. A., Al-Yusuf, A.R., Salem, S.N. et al. Pernicious anaemia among Arabs in Kuwait. J. Clin. Pathol. 1970, 23, p. 577-579.

2. Carter, M.E., Ardeman, S., Winocour, V. et al. Rheumatoid arthritis and pernicious anaemia. Ann. Rheum. Dis. 1968, 27, p. 454-456.

3. Graner, J.L. Addison, pernicious anemia and adrenal insufficiency. Can. Med. Assoc. J. 1985, 133, p. 855-857.

4. Hamilton, D.V. Systemic lupus erythematosus in a patient with Hashimoto´s thyroiditis and pernicious anaemia. J. R. Soc. Med. 1978, 71, p. 147-149.

5. Chanarin, I. Pernicious anemia. BMJ 1992, 304, p. 1584-1585.

6. Jayaratnam, F.J., Seah, C.S., Da Costa, J.L. et al. Pernicious anaemia among Asians in Singapore. BMJ 1967, 3, p. 18-20.

7. Morris, M.S., Jacques, P.F., Rosenberg, I.H. et al. Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am. J. Clin. Nutr. 2007, 85, p. 193-200.

8. Oliver, R.A. M., Baker, G.P. Juvenile pernicious anaemia and hypothyroidism. A family study. BMJ 1969, 2, p. 27-29.

9. Reynolds, E.H. Neurological aspects of folate and vitamin B12 metabolism. Clin. Haematol. 1976, 5, p. 661-696.

10. Sjöblom, S.M., Sipponen, P., Järvinen, H. Gastroscopic follow up of pernicious anaemia patients. Gut 1993, 34, p. 28-32.

11. Stabler, S.P., Allen, R.H., Savage, D.G. et al. Clinical spectrum and diagnosis of cobalamin deficiency. Blood 1990, 76, p. 871-881.

12. Stockbrügger, R.W., Menon, G.G., Beilby, J.O. et al. Gastroscopic screening in 80 patients with pernicious anaemia. Gut 1983, 24, p. 1141-1147.

13. Strickland, R.G., Baur, S., Ashworth, L.A.E. et al. A correlative study of immunological phenomena in pernicious anaemia. Clin. Exp. Immunol. 1971, 8, p. 25-36.

14. Strickland, R.G., Fisher, J.M., Lewin, K. et al. The response to prednisolone in atrophic gastritis: a possible effect on non-intrinsic factor-mediated vitamin B12 absorption. Gut 1973, 14, p. 13-19.

15. Ščudla, V. Megaloblastové anémie. In Indrák, K. a kol. Hematologie. Praha/Kroměříž: Triton, 2006, s. 44-50.

16. Ungar, B., Mathews, J.D., Tait, B.D. et al. HLA-DR patterns in pernicious anaemia. BMJ 1981, 282, p. 768-770.

17. Wall, A.J., Whittingham, S., Mackay, I.R. et al. Prednisolone and gastric atrophy. Clin. Exp. Immunol. 1968, 3, p. 359-366.

18. Whittingham, S., Youngchaiyud, U., Mackay, I.R. et al. Thyrogastric autoimmune disease. Studies on the cell-mediated immune system and histocompatibility antigens. Clin. Exp. Immunol. 1975, 19, p. 289-299.

19. Ye, W., Nyrén, O. Risk of cancers of the oesophagus and stomach by histology or subsite in patients hospitalised for pernicious anaemia. Gut 2003, 52, p. 938-941.

Štítky
General practitioner for children and adolescents General practitioner for adults
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