Relation Between Insulin Resistance and Amount of Visceral Adipose Tissue
Authors:
M. Bajzová 1; M. Kováčiková 1; M. Vítková 1; J. Polák 1; E. Klimčáková 1; A. Srp 2; T. Vedral 3; L. Mikulášek 4
; P. Šrámková 5; V. Štich 1; J. Hejnová 1
Authors place of work:
Oddělení tělovýchovného lékařství 3. LF UK, Praha
1; Radiodiagnostická klinika 3. LF UK a FNKV, Praha
2; Chirurgická klinika 3. LF UK a FNKV, Praha
3; Gynekologicko-porodnická klinika 3. LF UK a FNKV, Praha
4; ISCARE, Centrum pro léčbu obezity, Praha
5
Published in the journal:
Čas. Lék. čes. 2008; 147: 376-380
Category:
Original Article
Summary
Background.
Association of obesity with metabolic and cardiovascular complications depends on the adipose tissue distribution. The role of intraabdominal, i.e. visceral, adipose tissue in pathogenesis of insulin resistance is still not elucidated. The aim of this study was to investigate the relation between insulin resistance and contribution of visceral and subcutaneous fat in a group of women with a wide range of body weight.
Methods and Results.
62 women (age 21–66 years) among which 32 were non-obese and 30 obese (BMI > 30 kg/m²) were examined. The amount of visceral and subcutaneous fat was evaluated using computerized tomography, total body fat evaluated using bioimpedance, and the degree of insulin resistance was evaluated using glucose disposal (M) during euglycemic hyperinsulinemic clamp. Obese women had lower insulin sensitivity than non-obese (5.88 ± 2.17 vs 3.32 ± 1.44 mg/min/kg, p < 0.001) and higher absolute amount of visceral fat. However, the relative amount of visceral fat (related to total body fat or subcutaneous fat) was not different between the two groups. In the entire study group, the magnitude of insulin sensitivity did correlate with absolute amount of total and visceral fat, but no correlation with relative amount of visceral fat was found.
Conclusions.
The results suggest that the absolute amount of fat, either total or visceral, is a stronger predictor of the degree of insulin resistance than the relative contribution of visceral fat.
Key words:
insulin resistance, obesity, visceral fat. Ba.
Zdroje
1. Feinleib, M.: Epidemiology of obesity in relation to health hazards. Ann. Intern. Med., 1985, 103, s. 1019–1024.
2. Kandel, W. B.: Lipids, diabetes and coronary heart disease: insights from the Framingham Study. Am Heart J, 1985, 110, s. 1100–1107.
3. Keys, A.: Overweight, obesity, coronary heart disease and mortality. Nutr. Rev., 1980, 38, s. 297–307.
4. Mann, G. V.: The influence of obesity and health: part 2. N. Engl. J. Med., 1974, 291, s. 226–232.
5. Larsson, B.: Obesity, fat distribution and cardiovascular disease. Int. J. Obesity, 1991, 15, s. 53–57.
6. Vague, J.: The degrese of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout and uric calculous disease. Am. J. Clin. Nutr., 1956, 4, s. 20–34.
7. Kvist, H., Sjostrom, L., Tylen, U.: Adipose tissue volume determinations in women by computed tomography: technical considerations. Int. J. Obes., 1986, 10, s. 53–67.
8. Abate, N., Garg, A., Peshock, R. M. et al.: Relationship of generalized and regional adiposity to insulin senzitivity in men. J. Clin. Investic, 1995, 96, s. 88–98.
9. Pouliot, M. C., Espres, J-P., Naderu, A. et al.: Visceral obesity in men: associations with glukose tolerance, plasma insulin, and lipoproteid levels. Diabetes, 1992, 41, s. 826–834.
10. Lemieux, S., Tremblay, A., Prud-Homme, D. et al.: Seven--year changes in body fat and visceral adipose tissue in women: associations with index of plasma glucose-insulin homeostasis. Diabetes Care, 1996, 19, s. 983–991.
11. Banerji, M. A., Lebowitz, J., Chaiken, R. L. et al.: Relationship of visceral adipose tissue and glukose disposal is independent of sex in black NIDDM subjects. Am. J. Physiol., 1997, 273, s. E425–E432.
12. Fujioka, S., Matsuzawa, Y., Tokunaga, K., Tarui, S.: Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism., 1987, 36, s. 54–59.
13. Despres, J-P., Nadeau, A., Tremblay, A. et al.: Role of deep abdominal fat in the association between regional adipose tissue distribution and glucose tolerance in obese women. Diabetes, 1989, 38, s. 304–309.
14. Kuk, J. L., Church, T. S., Blair, S. N., Ross, R.: Does Measurment Site of Visceral and Abdominal Subcutaneous Adipose Tissue Alter Associations With the Metabolic Syndrome? Diabetes Care., 2006, 29, s. 679–684.
15. Goodpaster, B. H., Krishnaswami, S., Harris, T. B. et al.: Obesity, Regional Body Fat Distribution, and the Metabolic Syndrome in Older Men and Women. Arch. Intern. Med., 2005, 165, s. 777–783.
16. Frayn, K. N.: Visceral fat and insulin resistence-causativ or correlative? Brit. J. Nutr., 2000, 83 (Suppl. 1), s. S71–S77.
17. Abate, N., Garg, A., Peshock, R. M. et al.: Relationship of generalized and regional adiposity to insulin sensitivity in men with NIDDM. Diabetes., 1996, 45, s. 1684–1693.
18. DeFronzo, R. A., Tobin, J. D., Andres, R.: Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am. J. Physiol., 1979, 237, s. 214–223.
19. McLaughlin, T., Reaven, G., Abbasi, F. et al.: Is There a Simple Way to Identify Insulin-Resistant Individuals at Increased Risk of Cardiovascular Disease? Am. J. Cardiol., 2005, 96, s. 399–404.
20. Wajchenberg, B. L.: Subcutaneous and Visceral Adipose Tissue: Their Relation to the Metabolic Syndrome. Endocrine Reviews, 2000, 21, s. 697–738.
21. Reaven, G.: All obese individuals are not created equal: insulin resistance is the major determinant of cardiovascular disease in overweight/obese individuals. Diabetes Vasc Dis Res., 2005, 2, s. 105–112.
22. Hannon, T. S.: Use of markers of dyslipidemia to identify overweight youth with insulin resistance. Pediatr Diabetes, 2006, 7, s. 260–266.
23. Liao, Y., Kwon, S., Shaughnessy, S. et al.: Critical evaluation of adult treatment panel III criteria in identifying insulin resistance with dyslipidemia. Diabetes Care, 2004, 27, s. 978–983.
Štítky
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistČlánok vyšiel v časopise
Journal of Czech Physicians
- Metamizole at a Glance and in Practice – Effective Non-Opioid Analgesic for All Ages
- Advances in the Treatment of Myasthenia Gravis on the Horizon
- Metamizole vs. Tramadol in Postoperative Analgesia
- Spasmolytic Effect of Metamizole
- What Effect Can Be Expected from Limosilactobacillus reuteri in Mucositis and Peri-Implantitis?
Najčítanejšie v tomto čísle
- Is the Assessment of Serum Creatinine Reliable?
- Allergen Challenge Used to Diagnose Food Allergy – Oral Allergy Syndrome
- Relation Between Insulin Resistance and Amount of Visceral Adipose Tissue
- Conduct Disorders in Seven-year-old Children – Results of ELSPAC Study. 3. Postnatal Development