#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Perioperative chemotherapy in gastric cancer treatment – the surgeon’s view


Authors: MUDr. David Hoskovec
Authors place of work: 1. chirurgická klinika 1. LF UK a VFN, Praha
Published in the journal: Čas. Lék. čes. 2014; 153: 227-230
Category: Review Article

Summary

Contemporary European gastric cancer treatment guidelines recommend a short course of perioperative chemotherapy. This is supported by several randomized studies in which patients with perioperative chemotherapy had longer overall survival and better results in other parameters too (progression free survival, time to progression). The analysis of surgical therapy is given in this article. According to published data, in some patients extend of the surgery did not fulfill the requirements of contemporary surgical standards of care.

Keywords:
gastric cancer – perioperative chemotherapy – surgery – D2 lymphadenectomy


Zdroje

1. www.svod.cz

2. Tesař J, Krška Z, Zeman M. Karcinom žaludku a současnost. Rozhledy v chirurgii 2010; 89(3): 169–177.

3. De Manzoni G, Roviello F, Siquini W. Surgery in the multimodal management of gastrin cancer. Italy: Springer Verlag 2012.

4. Okines A, Verheij M, Allum W, Cunningham D, Cervantes A. Gastric cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology 2010; 21(Suppl 5): v50–v54.

5. Kol. Gastric cancer, NCCN Clinical practice guidelines in oncology. Dostupné na: www.nccn.org

6. Japanese Gastric Cancer Association: Japanese gastric cancer treatment guidelines 2010 (ver. 3). Gastric Cancer 2011; 14: 113–123.

7. Hoskovec D. Rozsah lymfadenektomie u karcinomu žaludku. Čas. Lék. čes. 2012; 151(4): 217–218.

8. Cunningham D, Allum WH, Stenning SP, et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer.

N Engl J Med 2006; 355: 11–20.

9. Ychou M, Boige V, Pignon JP, et al. Perioperative Chemotherapy Compared With Surgery Alone for Resectable Gastroesophageal Adenocarcinoma: A FNCLCC and FFCD Multicenter Phase III Trial, Published Ahead of Print on March 28, 2011 as 10.1200/JCO.2010.33.0597.

10. Schuhmacher Ch, Gretschel S, Lordick F, et al. Neoadjuvant chemotherapy compared with surgery alone for locally advanced cancer of the stomach and cardia: European Organisation for Research and Treatment of Cancer Randomized Trial 40954, Published Ahead of Print on November 8, 2010 as 10.1200/JCO.2009.26.6114.

11. Hartgrink HH, van de Velde CJ, Putter H, et al. Extended lymph node dissection for gastric cancer: Who may benefit? Final results of the randomized Dutch Gastric Cancer Group Trial. J Clin Oncol 2004; 22: 2069–2077.

12. Cuschieri A, Weeden S, Fielding J, et al. Patient survival after D1 and D2 resection for gastric cancer: Long-term results of the MRC randomized surgical trial. Surgical Co-operative Group. Br J Cancer 1999; 79: 1522–1530.

13. Songun I, Putter H, Meershoek-Klein Kranenbarg E, et al. Surgical treatment of gastric cancer: 15-year follow-up results of the randomised nationwide Dutch D1D2 trial Lancet Oncol 2010; 11: 439–449.

14. Yung-Jue Bang, Young-Woo Kim, Han-Kwang Yang et al. Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase open-label, randomised controlled trial. Lancet 2012; 379: 315–321.

15. Sakuramoto M, Sasako M, Yamaguchi T. Adjuvant chemotherapy for gastric cancer with s-1, an oral fluoropyrimidine N Engl J Med 2007; 357: 1810–1820.

16. Lee J, Lim DH, Kim S, et al. Phase III trial comparing capecitabine plus cisplatin versus capecitabine plus cisplatin with concurrent capecitabine radiotherapy in completely resected gastric cancer with d2 lymph node dissection: the ARTIST trial. J Clin Oncol 2011; 30: 268–273.

17. Macdonald JS, Smallex SR, Benedetti J, et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med 2001; 345: 725–730.

18. Smalley SR, Benedetti JK, Haller DG, et al. Updated analysis of SWOG-Directed Intergroup Study 0116: a phase iii trial of adjuvant radiochemotherapy versus observation after curative gastric cancer resection. Published ahead of print on May 14, 2012 as 10.1200/JCO.2011.36.7136.

Štítky
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist
Prihlásenie
Zabudnuté heslo

Zadajte e-mailovú adresu, s ktorou ste vytvárali účet. Budú Vám na ňu zasielané informácie k nastaveniu nového hesla.

Prihlásenie

Nemáte účet?  Registrujte sa

#ADS_BOTTOM_SCRIPTS#