Novinky v patologii prostaty

Karcinom prostaty je (mimo kožních nádorů) nejčastější malignitou mužů v rozvinutých zemích a jeho incidence v rozvojových zemích stále roste. Aktivní výzkum v posledních letech výrazně napomohl porozumění biologie a genetiky karcinomu prostaty, vedl ke zlepšení jeho diagnostiky i léčby. Gleasonův grading stále hraje v nastavení léčebné strategie pacientů s karcinomem prostaty zásadní roli. Tento grading se však od začátku vyvíjí a odráží tak postupné změny v klinické praxi. Modifikovaný Gleasonův grading byl zaveden v roce 2005 a výrazně změnil způsob, jakým je grade karcinomu prostaty stanovován, i způsob, jakým je pacient poté léčen. Několik histologických typů karcinomu prostaty s odlišnými klinickými a patologickými znaky bylo nově objeveno nebo předefinováno. Konečně, pochopení molekulárních a genetických mechanismů pomáhá nejen lépe porozumět patogenezi karcinomu prostaty, ale také identifikovat biomarkery pro lepší diagnostiku, stratifikaci rizika a klinický management onemocnění. Tento text stručně shrnuje nejnovější změny v Gleasonově gradingu, nové histologické typy a molekulární genetiku karcinomu prostaty.

Klíčová slova:
prostata - Gleasonovo skóre - intraduktální karcinom - neuroendokrinní diferenciace - molekulární genetika

Autoři: Weisheng Xu ¹; Ming Zhou ^1,2
Působiště autorů: Departments of Pathology, New York University Langone Medical Center, New York, NY, USA ¹; Departments of Pathology, New York University Langone Medical Center, New York, NY, USA ²
Vyšlo v časopise: Čes.-slov. Patol., 50, 2014, No. 4, p. 120-128
Kategorie: Přehledové články - Uropatologie

Souhrn

Klíčová slova:
prostata - Gleasonovo skóre - intraduktální karcinom - neuroendokrinní diferenciace - molekulární genetika

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