Coordinate Regulation of Stem Cell Competition by Slit-Robo and JAK-STAT Signaling in the Testis

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Stem cells adhere to niches, or local microenvironments, which provide essential maintenance cues. In the Drosophila testis niche, quiescent hub cells maintain adjacent germline and somatic stem cells (or cyst stem cells, CySCs) via local JAK-STAT signaling. Here, we show that the Slit-Robo and JAK-STAT pathways integrate to modulate stem cell-niche cell adhesion. The ligand Slit is expressed in the hub, and Slit's receptor Robo2, which is transcriptionally activated by JAK-STAT signaling, is required in adjacent CySCs to promote ECad-based adhesion to the hub. Abl tyrosine kinase acts downstream of Robo2 to attenuate CySC-hub adhesion and prevent CySCs from outcompeting neighboring cells from the niche. Interestingly, Robo receptors mediate stem cell-niche adhesion during hematopoiesis, but the mechanisms are not understood. We suggest that the Slit-Robo-Abelson and JAK-STAT pathways may coordinately regulate stem cell-niche cell adhesion more generally.

Vyšlo v časopise: Coordinate Regulation of Stem Cell Competition by Slit-Robo and JAK-STAT Signaling in the Testis. PLoS Genet 10(11): e32767. doi:10.1371/journal.pgen.1004713
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004713

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