Three RNA Binding Proteins Form a Complex to Promote Differentiation of Germline Stem Cell Lineage in

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In regenerative tissues, the successive differentiation of stem cell lineage is well controlled and coordinated with proper cell proliferation at each differentiation stage. Disruption of the control mechanism can lead to tumor growth or tissue degeneration. The germline stem cell lineage of Drosophila spermatogenesis provides an ideal research model to unravel the genetic network coordinating proliferation and differentiation. In a genetic screen, we identified a male-sterile mutant whose germ cells are under-differentiated and overproliferating. The responsible gene encodes an RNA-binding protein whose target belongs to a tumor suppressor family. We demonstrate that this and two other RNA-binding proteins form a physical and functional unit to ensure the proper differentiation and accurate proliferation of germline stem cell lineage.

Vyšlo v časopise: Three RNA Binding Proteins Form a Complex to Promote Differentiation of Germline Stem Cell Lineage in. PLoS Genet 10(11): e32767. doi:10.1371/journal.pgen.1004797
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004797

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