SAS-1 Is a C2 Domain Protein Critical for Centriole Integrity in

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Centrioles are microtubule-based organelles critical for forming cilia, flagella and centrosomes. Centrioles are very stable, but how such stability is ensured is poorly understood. We identified sas-1 as a component that contributes to centriole stability in C. elegans. Centrioles that lack sas-1 function loose their integrity, and our analysis reveals that sas-1 is particularly important for sperm-derived centrioles. Moreover, we show that SAS-1 binds and stabilizes microtubules in human cells, together leading us to propose that SAS-1 acts by stabilizing centriolar microtubules. We identify C2CD3 as a human homolog of SAS-1. C2CD3 is needed for the presence of the distal part of centrioles in human cells, and we thus propose that this protein family is broadly needed to maintain centriole structure.

Vyšlo v časopise: SAS-1 Is a C2 Domain Protein Critical for Centriole Integrity in. PLoS Genet 10(11): e32767. doi:10.1371/journal.pgen.1004777
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004777

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