Quantifying the Number of Pregnancies at Risk of Malaria in 2007: A Demographic Study

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Background:
Comprehensive and contemporary estimates of the number of pregnancies at risk of malaria are not currently available, particularly for endemic areas outside of Africa. We derived global estimates of the number of women who became pregnant in 2007 in areas with Plasmodium falciparum and P. vivax transmission.

Methods and Findings:
A recently published map of the global limits of P. falciparum transmission and an updated map of the limits of P. vivax transmission were combined with gridded population data and growth rates to estimate total populations at risk of malaria in 2007. Country-specific demographic data from the United Nations on age, sex, and total fertility rates were used to estimate the number of women of child-bearing age and the annual rate of live births. Subregional estimates of the number of induced abortions and country-specific stillbirths rates were obtained from recently published reviews. The number of miscarriages was estimated from the number of live births and corrected for induced abortion rates. The number of clinically recognised pregnancies at risk was then calculated as the sum of the number of live births, induced abortions, spontaneous miscarriages, and stillbirths among the population at risk in 2007. In 2007, 125.2 million pregnancies occurred in areas with P. falciparum and/or P. vivax transmission resulting in 82.6 million live births. This included 77.4, 30.3, 13.1, and 4.3 million pregnancies in the countries falling under the World Health Organization (WHO) regional offices for South-East-Asia (SEARO) and the Western-Pacific (WPRO) combined, Africa (AFRO), Europe and the Eastern Mediterranean (EURO/EMRO), and the Americas (AMRO), respectively. Of 85.3 million pregnancies in areas with P. falciparum transmission, 54.7 million occurred in areas with stable transmission and 30.6 million in areas with unstable transmission (clinical incidence <1 per 10,000 population/year); 92.9 million occurred in areas with P. vivax transmission, 53.0 million of which occurred in areas in which P. falciparum and P. vivax co-exist and 39.9 million in temperate regions with P. vivax transmission only.

Conclusions:
In 2007, 54.7 million pregnancies occurred in areas with stable P. falciparum malaria and a further 70.5 million in areas with exceptionally low malaria transmission or with P. vivax only. These represent the first contemporary estimates of the global distribution of the number of pregnancies at risk of P. falciparum and P. vivax malaria and provide a first step towards a more informed estimate of the geographical distribution of infection rates and the corresponding disease burden of malaria in pregnancy.

: Please see later in the article for the Editors' Summary

Vyšlo v časopise: Quantifying the Number of Pregnancies at Risk of Malaria in 2007: A Demographic Study. PLoS Med 7(1): e32767. doi:10.1371/journal.pmed.1000221
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pmed.1000221

Souhrn

Zdroje

1. RBM Pregnant women and Infants Geneva WHO Available:http://malaria.who.int/pregnantwomenandinfants.html Accessed 5 January 2010

2. World Health Organization 2004 A strategic framework for malaria prevention and control during pregnancy in the African region Brazzaville World Health Organization: Regional Office for Africa AFR/MAL/04/01 AFR/MAL/04/01

3. SnowRW

CraigM

DeichmannU

MarshK

1999 Estimating mortality, morbidity and disability due to malaria among Africa's non-pregnant population. Bull World Health Organ 77 624 640

4. United Nations Children's Fund 1998 The state of the world's children New York Oxford University Press

5. World Health Organization 2003 Geneva WHO Available: http://www.who.int/features/2003/04b/en/ Accessed 5 January 2010

6. BairdJK

2007 Neglect of Plasmodium vivax malaria. Trends Parasitol 23 533 539

7. HaySI

GuerraCA

TatemAJ

NoorAM

SnowRW

2004 The global distribution and population at risk of malaria: past, present, and future. Lancet Infect Dis 4 327 336

8. SinghN

ShuklaMM

SharmaVP

1999 Epidemiology of malaria in pregnancy in central India. Bull World Health Organ 77 567 572

9. NostenF

McGreadyR

SimpsonJA

ThwaiKL

BalkanS

1999 Effects of Plasmodium vivax malaria in pregnancy. Lancet 354 546 549

10. PoespoprodjoJR

FobiaW

KenangalemE

LampahDA

WarikarN

2008 Adverse pregnancy outcomes in an area where multidrug-resistant plasmodium vivax and Plasmodium falciparum infections are endemic. Clin Infect Dis 46 1374 1381

11. BalkDL

DeichmannU

YetmanG

PozziF

HaySI

2006 Determining global population distribution: methods, applications and data. Adv Parasitol 62 119 156

12. HaySI

SnowRW

2006 The Malaria Atlas Project: developing global maps of malaria risk. PLoS Med 3 e473 doi:10.1371/journal.pmed.0030473

13. SnowRW

GuerraCA

NoorAM

MyintHY

HaySI

2005 The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature 434 214 217

14. HaySI

SmithDL

SnowRW

2008 Measuring malaria endemicity from intense to interrupted transmission. Lancet Infect Dis 8 369 378

15. GuerraCA

GikandiPW

TatemAJ

NoorAM

SmithDL

2008 The limits and intensity of Plasmodium falciparum transmission: implications for malaria control and elimination worldwide. PLoS Med 5 e38 doi:10.1371/journal.pmed.0050038

16. GuerraCA

SnowRW

HaySI

2006 Mapping the global extent of malaria in 2005. Trends Parasitol 22 353 358

17. GuerraCA

SnowRW

HaySI

2006 Defining the global spatial limits of malaria transmission in 2005. Adv Parasitol 62 157 179

18. GuerraCA

2007 Mapping the contemporary global distribution limits of malaria using empirical data and expert opinion Oxford University of Oxford 258

19. TatemAJ

GuerraCA

KabariaCW

NoorAM

HaySI

2008 Human population, urban settlement patterns and their impact on Plasmodium falciparum malaria endemicity. Malar J 7 218

20. Center for International Earth Science Information Network (CIESIN)/Columbia University; International Food Policy Research Institute (IFPRI)/the World Bank/and Centro Internacional de Agricultura Tropical (CIAT) 2007 Global Rural Urban Mapping Project (GRUMP) alpha: Gridded Population of the World; version 2 with urban reallocation (GPW-UR) Palisades (New York) CIESIN; Columbia University Available: http://sedac.ciesin.columbia.edu/gpw. Accessed 5 January 2010

21. United Nations Population Division; Department of Economic and Social Affairs 2007 World population prospects; the 2006 revision; ST/ESA/SER.A/261/ES New York United Nations

22. HaySI

NoorAM

NelsonA

TatemAJ

2005 The accuracy of human population maps for public health application. Trop Med Int Health 10 1073 1086

23. UNPD 2006 World population prospects: population database. Available: http://esa.un.org/unpp/. Accessed 5 January 2010

24. SedghG

HenshawS

SinghS

AhmanE

ShahIH

2007 Induced abortion: estimated rates and trends worldwide. Lancet 370 1338 1345

25. StantonC

LawnJE

RahmanH

Wilczynska-KetendeK

HillK

2006 Stillbirth rates: delivering estimates in 190 countries. Lancet 367 1487 1494

26. LeridonH

1977 Human fertility: the basic components (Table 4.20) Chicago University of Chicago Press

27. HammersloughCR

1992 Estimating the probability of spontaneous abortion in the presence of induced abortion and vice versa. Public Health Rep 107 269 277

28. HenshawSK

BinkinNJ

BlaineE

SmithJC

1985 A portrait of American women who obtain abortions. Fam Plann Perspect 17 90 96

29. World Health Organization 2009 WHO regional offices Geneva World Health Organisation Available: http://www.who.int/about/regions/en/ Accessed 5 January 2010

30. DesaiM

ter KuileFO

NostenF

McGreadyR

AsamoaK

2007 Epidemiology and burden of malaria in pregnancy. Lancet Infect Dis 7 93 104

31. HaySI

GuerraCA

GethingPW

PatilAP

TatemAJ

2009 A world malaria map: Plasmodium falciparum endemicity in 2007. PLoS Med 6 e1000048 doi:10.1371/journal.pmed.1000048