#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

The Mouse Resistance Protein Irgm1 (LRG-47): A Regulator or an Effector of Pathogen Defense?


article has not abstract


Vyšlo v časopise: The Mouse Resistance Protein Irgm1 (LRG-47): A Regulator or an Effector of Pathogen Defense?. PLoS Pathog 6(7): e32767. doi:10.1371/journal.ppat.1001008
Kategorie: Opinion
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1001008

Souhrn

article has not abstract


Zdroje

1. BekpenC

HunnJP

RohdeC

ParvanovaI

GuethleinL

2005 The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage. Genome Biol 6 R92

2. CollazoCM

YapGS

SempowskiGD

LusbyKC

TessarolloL

2001 Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. J Exp Med 194 181 188

3. TaylorGA

CollazoCM

YapGS

NguyenK

GregorioTA

2000 Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP. Proc Natl Acad Sci U S A 97 751 755

4. SantiagoHC

FengCG

BaficaA

RoffeE

ArantesRM

2005 Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth. J Immunol 175 8165 8172

5. TaylorGA

2007 IRG proteins: key mediators of interferon-regulated host resistance to intracellular pathogens. Cell Microbiol 9 1099 1107

6. MacMickingJD

TaylorGA

McKinneyJD

2003 Immune control of tuberculosis by IFN-gamma-inducible LRG-47. Science 302 654 659

7. FengCG

Collazo-CustodioCM

EckhausM

HienyS

BelkaidY

2004 Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia. J Immunol 172 1163 1168

8. CoersJ

Bernstein-HanleyI

GrotskyD

ParvanovaI

HowardJC

2008 Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10. J Immunol 180 6237 6245

9. HenrySC

DaniellX

IndaramM

WhitesidesJF

SempowskiGD

2007 Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47). J Immunol 179 6963 6972

10. GutierrezMG

MasterSS

SinghSB

TaylorGA

ColomboMI

2004 Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 119 753 766

11. SinghSB

DavisAS

TaylorGA

DereticV

2006 Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria. Science 313 1438 1441

12. LingYM

ShawMH

AyalaC

CoppensI

TaylorGA

2006 Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages. J Exp Med 203 2063 2071

13. XuH

WuZY

FangF

GuoL

ChenD

2010 Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cells. Faseb J 24 1583 1592

14. HenrySC

DaniellXG

BurroughsAR

IndaramM

HowellDN

2009 Balance of Irgm protein activities determines IFN-{gamma}-induced host defense. J Leukoc Biol 85 877 885

15. FengCG

WeksbergDC

TaylorGA

SherA

GoodellMA

2008 The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. Cell Stem Cell 2 83 89

16. FengCG

ZhengL

JankovicD

BaficaA

CannonsJL

2008 The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death. Nat Immunol 9 1279 1287

17. FengCG

ZhengL

LenardoMJ

SherA

2009 Interferon-inducible immunity-related GTPase Irgm1 regulates IFNgamma-dependent host defense, lymphocyte survival and autophagy. Autophagy 5 232 234

18. BoehmU

GuethleinL

KlampT

OzbekK

SchaubA

1998 Two families of GTPases dominate the complex cellular response to IFN-gamma. J Immunol 161 6715 6723

19. HunnJP

Koenen-WaismanS

PapicN

SchroederN

PawlowskiN

2008 Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii. Embo J 27 2495 2509

20. PapicN

HunnJP

PawlowskiN

ZerrahnJ

HowardJC

2008 Inactive and active states of the interferon-inducible resistance GTPase, Irga6, in vivo. J Biol Chem 283 32143 32151

21. MartensS

ParvanovaI

ZerrahnJ

GriffithsG

SchellG

2005 Disruption of Toxoplasma gondii Parasitophorous Vacuoles by the Mouse p47-Resistance GTPases. PLoS Pathog 1 e24 doi:10.1371/journal.ppat.0010024

22. CarlowDA

TehSJ

TehHS

1998 Specific antiviral activity demonstrated by TGTP, a member of a new family of interferon-induced GTPases. J Immunol 161 2348 2355

23. AdvaniAS

DressmanHK

QuirozM

TaylorGA

PendergastAM

2004 Elevated expression of a subset of interferon inducible genes in primary bone marrow cells expressing p185 Bcr-Abl versus p210 Bcr-Abl by DNA microarray analysis. Leuk Res 28 285 294

24. TerskikhAV

EasterdayMC

LiL

HoodL

KornblumHI

2001 From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Proc Natl Acad Sci U S A 98 7934 7939

25. VeneziaTA

MerchantAA

RamosCA

WhitehouseNL

YoungAS

2004 Molecular signatures of proliferation and quiescence in hematopoietic stem cells. PLoS Biol 2 e301 doi:10.1371/journal.pbio.0020301

26. BenceNF

SampatRM

KopitoRR

2001 Impairment of the ubiquitin-proteasome system by protein aggregation. Science 292 1552 1555

27. MartensS

SabelK

LangeR

UthaiahR

WolfE

2004 Mechanisms Regulating the Positioning of Mouse p47 Resistance GTPases LRG-47 and IIGP1 on Cellular Membranes: Retargeting to Plasma Membrane Induced by Phagocytosis. J Immunol 173 2594 2606

28. ZhaoYO

Konen-WaismanS

TaylorGA

MartensS

HowardJC

2010 Localisation and mislocalisation of the interferon-inducible immunity-related GTPase, Irgm1 (LRG-47) in mouse cells. PLoS ONE 5 e8648 doi:10.1371/journal.pone.0008648

29. TaylorGA

StauberR

RulongS

HudsonE

PeiV

1997 The inducibly expressed GTPase localizes to the endoplasmic reticulum, independently of GTP binding. J Biol Chem 272 10639 10645

30. ZhaoYO

KhaminetsA

HunnJP

HowardJC

2009 Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell death. PLoS Pathog 5 e1000288 doi:10.1371/journal.ppat.1000288

31. Bernstein-HanleyI

CoersJ

BalsaraZR

TaylorGA

StarnbachMN

2006 The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice. Proc Natl Acad Sci U S A 103 14092 14097

32. HenrySC

TraverM

DaniellX

IndaramM

OliverT

2010 Regulation of macrophage motility by Irgm1. J Leukoc Biol 87 333 343

33. RubinszteinDC

2006 The roles of intracellular protein-degradation pathways in neurodegeneration. Nature 443 780 786

34. BironCA

NguyenKB

PienGC

CousensLP

Salazar-MatherTP

1999 Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu Rev Immunol 17 189 220

35. YokoyamaWM

KimS

FrenchAR

2004 The dynamic life of natural killer cells. Annu Rev Immunol 22 405 429

36. TiwariS

ChoiHP

MatsuzawaT

PypaertM

MacMickingJD

2009 Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria. Nat Immunol 10 907 917

Štítky
Hygiena a epidemiológia Infekčné lekárstvo Laboratórium

Článok vyšiel v časopise

PLOS Pathogens


2010 Číslo 7
Najčítanejšie tento týždeň
Najčítanejšie v tomto čísle
Kurzy

Zvýšte si kvalifikáciu online z pohodlia domova

Aktuální možnosti diagnostiky a léčby litiáz
nový kurz
Autori: MUDr. Tomáš Ürge, PhD.

Všetky kurzy
Prihlásenie
Zabudnuté heslo

Zadajte e-mailovú adresu, s ktorou ste vytvárali účet. Budú Vám na ňu zasielané informácie k nastaveniu nového hesla.

Prihlásenie

Nemáte účet?  Registrujte sa

#ADS_BOTTOM_SCRIPTS#