The Role of Chemokines during Viral Infection of the CNS

1. LaneTE

AsensioVC

YuN

PaolettiAD

CampbellIL

1998 Dynamic regulation of alpha- and beta-chemokine expression in the central nervous system during mouse hepatitis virus-induced demyelinating disease. J Immunol 160 970 978

2. ChristensenJE

SimonsenS

FengerC

SorensenMR

MoosT

2009 Fulminant lymphocytic choriomeningitis virus-induced inflammation of the CNS involves a cytokine-chemokine-cytokine-chemokine cascade. J Immunol 182 1079 1087

3. SoEY

KimBS

2009 Theiler's virus infection induces TLR3-dependent upregulation of TLR2 critical for proinflammatory cytokine production. Glia 57 1216 1226

4. AravalliRN

HuS

RowenTN

PalmquistJM

LokensgardJR

2005 Cutting edge: TLR2-mediated proinflammatory cytokine and chemokine production by microglial cells in response to herpes simplex virus. J Immunol 175 4189 4193

5. van MarleG

HenryS

TodorukT

SullivanA

SilvaC

2004 Human immunodeficiency virus type 1 Nef protein mediates neural cell death: a neurotoxic role for IP-10. Virology 329 302 318

6. KleinRS

LinE

ZhangB

LusterAD

TollettJ

2005 Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis. J Virol 79 11457 11466

7. SassevilleVG

SmithMM

MackayCR

PauleyDR

MansfieldKG

1996 Chemokine expression in simian immunodeficiency virus-induced AIDS encephalitis. Am J Pathol 149 1459 1467

8. PrehaudC

MegretF

LafageM

LafonM

2005 Virus infection switches TLR-3-positive human neurons to become strong producers of beta interferon. J Virol 79 12893 12904

9. WuestT

AustinBA

UematsuS

ThapaM

AkiraS

2006 Intact TRL 9 and type I interferon signaling pathways are required to augment HSV-1 induced corneal CXCL9 and CXCL10. J Neuroimmunol 179 46 52

10. IrelandDD

StohlmanSA

HintonDR

AtkinsonR

BergmannCC

2008 Type I interferons are essential in controlling neurotropic coronavirus infection irrespective of functional CD8 T cells. J Virol 82 300 310

11. ScottEP

BraniganPJ

Del VecchioAM

WeissSR

2008 Chemokine expression during mouse-hepatitis-virus-induced encephalitis: contributions of the spike and background genes. J Neurovirol 14 5 16

12. ZhangB

ChanYK

LuB

DiamondMS

KleinRS

2008 CXCR3 mediates region-specific antiviral T cell trafficking within the central nervous system during West Nile virus encephalitis. J Immunol 180 2641 2649

13. YanXT

TumpeyTM

KunkelSL

OakesJE

LauschRN

1998 Role of MIP-2 in neutrophil migration and tissue injury in the herpes simplex virus-1-infected cornea. Invest Ophthalmol Vis Sci 39 1854 1862

14. HoskingMP

LiuL

RansohoffRM

LaneTE

2009 A protective role for ELR+ chemokines during acute viral encephalomyelitis. PLoS Pathog 5 e1000648 doi:10.1371/journal.ppat.1000648

15. KimJV

KangSS

DustinML

McGavernDB

2009 Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis. Nature 457 191 195

16. McCandlessEE

ZhangB

DiamondMS

KleinRS

2008 CXCR4 antagonism increases T cell trafficking in the central nervous system and improves survival from West Nile virus encephalitis. Proc Natl Acad Sci U S A 105 11270 11275

17. AsensioVC

CampbellIL

1997 Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis. J Virol 71 7832 7840

18. LiuMT

ChenBP

OertelP

BuchmeierMJ

ArmstrongD

2000 The T cell chemoattractant IFN-inducible protein 10 is essential in host defense against viral-induced neurologic disease. J Immunol 165 2327 2330

19. WuestTR

CarrDJ

2008 Dysregulation of CXCR3 signaling due to CXCL10 deficiency impairs the antiviral response to herpes simplex virus 1 infection. J Immunol 181 7985 7993

20. TrifiloMJ

Montalto-MorrisonC

StilesLN

HurstKR

HardisonJL

2004 CXC chemokine ligand 10 controls viral infection in the central nervous system: evidence for a role in innate immune response through recruitment and activation of natural killer cells. J Virol 78 585 594

21. MuseM

KaneJA

CarrDJ

FarberJM

LaneTE

2008 Insertion of the CXC chemokine ligand 9 (CXCL9) into the mouse hepatitis virus genome results in protection from viral-induced encephalitis and hepatitis. Virology 382 132 144

22. GlassWG

LimJK

CholeraR

PletnevAG

GaoJL

2005 Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection. J Exp Med 202 1087 1098

23. GlassWG

LiuMT

KuzielWA

LaneTE

2001 Reduced macrophage infiltration and demyelination in mice lacking the chemokine receptor CCR5 following infection with a neurotropic coronavirus. Virology 288 8 17

24. LimJK

LouieCY

GlaserC

JeanC

JohnsonB

2008 Genetic deficiency of chemokine receptor CCR5 is a strong risk factor for symptomatic West Nile virus infection: a meta-analysis of 4 cohorts in the US epidemic. J Infect Dis 197 262 265

25. Fung-LeungWP

KundigTM

ZinkernagelRM

MakTW

1991 Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression. J Exp Med 174 1425 1429

26. ChristensenJE

de LemosC

MoosT

ChristensenJP

ThomsenAR

2006 CXCL10 is the key ligand for CXCR3 on CD8+ effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system. J Immunol 176 4235 4243

27. ChristensenJE

NansenA

MoosT

LuB

GerardC

2004 Efficient T-cell surveillance of the CNS requires expression of the CXC chemokine receptor 3. J Neurosci 24 4849 4858

28. HoferMJ

CarterSL

MullerM

CampbellIL

2008 Unaltered neurological disease and mortality in CXCR3-deficient mice infected intracranially with lymphocytic choriomeningitis virus-Armstrong. Viral Immunol 21 425 433

29. LiuMT

KeirsteadHS

LaneTE

2001 Neutralization of the chemokine CXCL10 reduces inflammatory cell invasion and demyelination and improves neurological function in a viral model of multiple sclerosis. J Immunol 167 4091 4097

30. GlassWG

HickeyMJ

HardisonJL

LiuMT

ManningJE

2004 Antibody targeting of the CC chemokine ligand 5 results in diminished leukocyte infiltration into the central nervous system and reduced neurologic disease in a viral model of multiple sclerosis. J Immunol 172 4018 4025

31. VergoteD

ButlerGS

OomsM

CoxJH

SilvaC

2006 Proteolytic processing of SDF-1alpha reveals a change in receptor specificity mediating HIV-associated neurodegeneration. Proc Natl Acad Sci U S A 103 19182 19187

32. KaulM

ZhengJ

OkamotoS

GendelmanHE

LiptonSA

2005 HIV-1 infection and AIDS: consequences for the central nervous system. Cell Death Differ 12 Suppl 1 878 892

33. Gonzalez-ScaranoF

Martin-GarciaJ

2005 The neuropathogenesis of AIDS. Nat Rev Immunol 5 69 81

34. KolodziejA

SchulzS

GuyonA

WuDF

PfeifferM

2008 Tonic activation of CXC chemokine receptor 4 in immature granule cells supports neurogenesis in the adult dentate gyrus. J Neurosci 28 4488 4500