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New antiretrovirals and the Revised European HIV/AIDS classification


Authors: D. Sedláček
Authors place of work: Vedoucí: doc. MUDr. Dalibor Sedláček, CSc. ;  AIDS centrum FN Plzeň
Published in the journal: Prakt. Lék. 2008; 88(11): 643-647
Category: Various Specialization

Summary

This article provides essential information on new antiretrovirals recently introduced into clinical practice. The second part of the article offers a comparison between the current revised European HIV/AIDS classification and the original classification published in 1993.

Key words:
new antiretrovirals, etravirine, raltegravir, maraviroc, therapy of HIV/AIDS, classification of HIV infection.


Zdroje

1. Castro, K.G., Ward, J.W., Slutsker, L. et al. 1993 Revised Classification System for HIV Infection and Expanded Surveillance Case Definition for AIDS Among Adolescents and Adults. MMWR. 1992 / 41(RR-17). Dostupné na: http://www. cdc.gov/mmwr/preview/mmwrhtml/00018871.htm

2. DeJesus, E., Berger, D., Markowitz, M. et al. Antiviral activity, pharmacokinetics, and dose response of the HIV-1 integrase inhibitor GS-9137 (JTK-303) in treatment-naive and treatment-experienced patients. J. Acquir. Immune Defic. Syndr. 2006, 43(1), p. 1-5.

3. DHHS Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. January 29, 2008. Dostupné na: http://aidsinfo.nih.gov/contentfiles/AdultandAdolescentGL.pdf

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10. Madruga, J.V., Cahn, P., Grinsztejn, B. et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet 2007, 370(9581), p. 29-38.

11. Markowitz, M., Morales-Ramirez, J.O., Nguyen, B-Y. et al. Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals. J. Acquir. Immune Defic. Syndr. 2006, 43(5), p. 509-515.

12. Moore, J.P., Kitchen, S.G., Pugach, P., Zack. J.A. The CCR5 and CXCR4 coreceptors—central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection. AIDS Res. Hum. Retroviruses 2004, 20(1), p. 111-126.

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14. WHO Regional Office for Europe. Annex 2. Revised WHO clinical staging of HIV/AIDS for adults and adolescents. In: Eramova I, Matic S, Munz M.: HIV/AIDS teatment and the clinical protocols for the WHO European region. World Health Organization, 2007, p. 18-64.

Štítky
General practitioner for children and adolescents General practitioner for adults
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