Problems of viral hepatitis in patients infected with HIV
Authors:
V. Aster; L. Machala 1; H. Rozsypal; D. Jilich; M. Staňková
Authors place of work:
Univerzita Karlova, Praha
1. lékařská fakulta
III. klinika infekčních a tropických nemocí
Přednosta: doc. MUDr. Michal Holub, Ph. D.
; Klinika infekčních nemocí, FN Na Bulovce, Praha
Přednosta: MUDr. Hana Roháčová, Ph. D.
1
Published in the journal:
Prakt. Lék. 2008; 88(11): 637-642
Category:
Reviews
Summary
The co-infection of HIV and HCV or HBV is very common since all these agents share a very similar epidemiology. Approximately 30 % of all HIV positive patients are co-infected with HCV and in some cohorts up to 90 % of HIV positive patients have markers of HBV infection. Co-infection with HIV leads to the more rapid progression of both hepatitis C and B, but the presence of either HCV or HBV does not substantially influence the course of the HIV infection. The combination of pegylated interferon and ribavirin is the gold standard for therapy of HIV/HCV co-infected patients. Interferons and nucleoside analogues are used in the treatment of chronic hepatitis B, which often have dual antiviral activity against HIV and HBV. The course of hepatitis A is not modified in HIV positive patients. Co-infection with hepatitis G has been demonstrated to have some positive effect on the course of the HIV infection.
Key words:
HIV, HCV, HBV, hepatitis, co-infection.
Zdroje
1. Sulkowski, M. Viral hepatitis and HIV coinfection. J. Hepatol. 2008, 48(2), p. 353-367.
2. Pol, S., Soriano V. Management of chronic hepatitis C virus infection in HIV-infected patients. Clinical Infectious Diseases 2008, 47(1), p. 94-101.
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5. Sheng, W.H. W.H, Hung, C.C. Kao, J.H. et al. Impact of hepatitis D virus infection on the long-term outcomes of patients with hepatitis B virus and HIV coinfection in the era of highly active antiretroviral therapy: a matched cohort study. Clinical Infectious Diseases 2007, 44(7), p. 988-995.
6. Wedemeyer, H., Heidrich, B., Manns, M.P. Hepatitis D virus infection - not a vanishing disease in Europe! Hepatology 2007, 45(5), p. 1331-1332.
7. Herman, K., Shire, N., Rouster, S. et al. Viral kinetics in Hepatitis C or Hepatitis C/HIV-infected patients. Gastroenterology 2005, 128, p. 313-327.
8. Tillmann, H.L., Heiken, H., Knapik-Botor, A. et al. Infection with GB Virus C and reduced mortality among HIV-infected patients. New Engl. J. Med. 2001, 345(10), p. 715-724.
Štítky
General practitioner for children and adolescents General practitioner for adultsČlánok vyšiel v časopise
General Practitioner
2008 Číslo 11
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