Changes of the laboratory indicators of hemostasis in hepatopathy

Česká verzia

Authors: R. Hrabcová ^1,4; P. Kessler ²; J. Gumulec ¹; M. Kouri ³
Authors place of work: Ústav klinické hematologie FN Ostrava, přednosta prim. MUDr. Jaromír Gumulec ¹; Oddělení hematologie a transfuziologie Nemocnice Pelhřimov, p. o., přednosta prim. MUDr. Petr Kessler ²; BioMerieux, South Africa, general manager Marcin Kouri ³; SPADIA LAB a. s., Česká republika, ředitel RNDr. Martin Radina ⁴
Published in the journal: Vnitř Lék 2010; 56(Supplementum 1): 120-122
Category: 16th Parizek's Days, Ostrava-Poruba, March 25th –26th 2010

Summary

The liver has a central role in hemostasis. It is the major site of synthesis of the coagulation factors, inhibitors and components of fibrinolytic system. The liver also functions as a site for clearance of their activated forms from the circulation. Liver disease leads to a shift in the delicately controlled hemostatic system in both primary and secondary hemostasis.

Key words:
liver disease – thrombocytopenia – platelet dysfunction – coagulation abnormalities – DIC

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