Use of platelet lysate for mesenchymal stem cell cultivation

Česká verzia

Authors: E. Matějková ¹; V. Foltánková ²; J. Michálek ²; B. Kubešová ¹
Authors place of work: Tkáňová banka FN Brno, pracoviště Bohunice, přednostka prim. MUDr. Barbara Kubešová ¹; Univerzitní centrum buněčné imunoterapie, Babákův výzkumný institut Lékařské fakulty MU Brno, přednosta prof. MUDr. Roman Hájek, CSc. ²
Published in the journal: Vnitř Lék 2010; 56(Supplementum 1): 46-50
Category: 16th Parizek's Days, Ostrava-Poruba, March 25th –26th 2010

Summary

Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal stem cells that can be isolated from many adult tissues. They can differentiate into cells of the mesodermal lineage, such as adipocytes, osteocytes and chondrocytes, as well as cells of other embryonic lineages. MSCs can interact with cells of both the innate and adaptive immune systems, leading to the modulation of several effector functions. After in vivo administration, MSCs induce peripheral tolerance and migrate to injured tissues, where they can inhibit the release of pro-inflammatory cytokines and promote the survival of damaged cells. This article recapitulates experimental data of MSC sources and mechanisms of MSC- isolation and cultivation according to GMP (good manufacture practice) standards.

Key words:
mesenchymal stem cells – platelet lysate

Zdroje

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