Thrombocytopenia in a newborn

Česká verzia

Authors: D. Wechsler; T. Jimramovský; Z. Doležel
Authors place of work: Pediatrická klinika Lékařské fakulty MU a FN Brno, Dětská nemocnice, přednosta prof. MUDr. Zdeněk Doležel, CSc.
Published in the journal: Vnitř Lék 2010; 56(Supplementum 1): 51-54
Category: 16th Parizek's Days, Ostrava-Poruba, March 25th –26th 2010

Summary

The article adresses in newborn with thrombocytopenias. It summarizes possible etiology and briefly describes the possibility of categorizing the throbocytopenias in newborns. Diagnostic and therapeutic options are outlined. The article is concluded with a case report on newborn with neonatal alloimmune thrombocytopenia.

Key words:
newborn – thrombocytopenia – neonatal alloimmune thrombocytopenia

Zdroje

1. Forestier F, Daffos F, Galacteros F. Haematological values of 163 normal fetuses between 18 and 30 weeks of gestation. Pediatr Res 1986; 20: 342– 346.

2. Sainio S, Jarvenpaa AS, Renlund M et al. Thrombocytopenain terminfants: a populationbased study. Obstetr Gynecol 2000; 95: 441– 446.

3. Mehta P, Rohitkumar V, Neumann L et al. Thrombocytpenia in the high risk infant. J Pediatr 1980; 108: 791– 794.

4. Roberts I, Murray NA. Neonatal thrombocytopenia: causes and management. Arch Dis Child Fetal Neonatal Ed 2003; 88: 359– 364.

5. Castle V, Andrew M, Kelton J et al. Frequency and mechanism of neonatal thrombocytopenia. J Pediatr 1986; 108: 749– 755.

6. Glade- Bender J, McFarland JG, Kaplan C t al. Anti-HPA- 3A induces severe neonatal alloimmune thrombocytopenia. J Pediatr 2001; 138: 862– 867.

7. Forestier F, Hohlfeld P. Management of fetal and neonatal alloimmune thrombocytopenia. Biol Neonate 1998; 74: 395– 401.

8. Overton TG, Duncan KR, Jolly M et al. Serial aggressive platelet transfusion for fetal alloimmune thrombocytopenia: platelet dynamics and perinatal outcome. Am J Obstet Gynecol 2002; 186: 826– 831.

9. Ranasinghe E, Walton JD, Hurd CM et al. Provision of platelet support for fetuses and neonates affected by severe fetomaternal alloimmune thrombocytopenia. Br J Haematol 2001; 113: 40– 42.