Thrombocytopenia in patients with proved antiphospholipid antibodies or with antiphospholipid syndrome

Česká verzia

Authors: A. Buliková ¹; D. Haruštiaková ²; J. Zavřelová ¹; L. Dušek ²; M. Penka ¹
Authors place of work: Oddělení klinické hematologie FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Miroslav Penka, CSc. ¹; Institut biostatistiky a analýz Lékařské a Přírodovědecké fakulty MU Brno, přednosta doc. RNDr. Ladislav Dušek, CSc. ²
Published in the journal: Vnitř Lék 2010; 56(Supplementum 1): 81-90
Category: 16th Parizek's Days, Ostrava-Poruba, March 25th –26th 2010

Summary

Thrombocytopenia in patients with antiphospholipid antibodies (APA) is relative common finding which is found in approximately 20–40% of cases. There are likely different mechanisms resulting in thrombocytopenia in these situations. Authors summarise current knowledge of pathophysiology, clinical manifestations and management of APA-associated thrombocytopenia and other causes of decreased value of peripheral blood platelets in APA positive persons.

Key words:
thrombocytopenia – antiphospholipid antibodies – pathophysiology – treatment

Zdroje

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