Endocrine orbitopathy – the topic still alive

Česká verzia

Authors: Zdeněk Fryšák; David Karásek; Milan Halenka
Authors place of work: III. interní klinika – nefrologická, revmatologická a endokrinologická LF UP a FN Olomouc
Published in the journal: Vnitř Lék 2016; 62(Suppl 3): 56-62
Category: Reviews

Summary

Endocrine orbitopathy (EO) must be understood mainly as a result of oxidative stress. The pathological process finally affects both the appearance and vision of the patient. In the case of inappropriate or late treatment or lack of patient cooperation, it significantly influences the quality of life of those affected. In spite of the sophisticated diagnostic algorithms, in some cases it is difficult to confirm the diagnosis of EO. The range of laboratory methods, the essential part of the diagnostic process, has only recently been extended by the possibility of quantification of specific, stimulating immunoglobulins (TSI). A major shortcoming may be seen in an undervalued importance of orbital ultrasonography, in particular of the eye muscles (US).

Key words:
biological treatment – endocrine orbitopathy (EO) – Graves-Basedow disease (GB) – “hashitoxicosis” (HTX) – hyaluronan synthase 2 (HAS2) – thyroid-blocking immunoglobulins (TBI) – thyroid-stimulating immunoglobulins (TSI) – hyaluronic acid (HA) – lymphocytary, Hashimoto‘s thyroiditis (HT) – pulse therapy – TSH-receptor – transcription factors FOXOs – orbital ultrasonography, mainly of the eye muscles (US)

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