Vitamin D and autoimmune thyroid diseases

Česká verzia

Authors: Karel Vondra
Authors place of work: Endokrinologický ústav, Praha
Published in the journal: Vnitř Lék 2016; 62(Suppl 3): 121-125
Category: Reviews

Summary

From the recent literature data it may be concluded that vitamin D deficiency is associated with increased risk of thyroid autoimmunity development and thus should be considered as an additional important risk factor for both chronic autoimmune thyroiditis (postpartum thyroiditis including) and Graves´ disease. A higher risk of Graves´ disease development is also associated with several polymorphisms in the gene encoding for vitamin D binding protein and for the specific receptor of active form of vitamin D – 1,25-(OH)₂D₃ in the respective target cells. Whether careful supplementation with vitamin D aimed to normalize low 25(OH)D levels brings preventive or therapeutic effect is subject to further research.

Key words:
autoimmune thyroiditis – D vitamin deficiency – D vitamin supplementation – Graves´disease

Zdroje

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