TSH secreting adenomas

Česká verzia

Authors: Jana Ježková; Josef Marek
Authors place of work: III. interní klinika 1. LF UK a VFN v Praze
Published in the journal: Vnitř Lék 2016; 62(Suppl 3): 77-81
Category: Reviews

Summary

Adenomas which secrete thyrotropic hormone (thyrotropinomas) are rare and constitute less than 3 % of pituitary adenomas. In laboratory studies there is a typical elevation of thyroid hormones with nonsupressible TSH. In differential diagnostics it is necessary to distinguish above all the syndrome of resistance to thyroid hormones. Clinical symptoms are usually mild and correspond to symptoms of hyperthyroidism. Goiter is a common finding. In 80 % of cases thyrotropinomas are diagnosed in a stage of invasively growing macroadenoma. The primary treatment is neurosurgical removal adenoma which results in cure in 40 % of patients. Other treatment options include radiation therapy and medical treatment (treatment with somatostatin analogues). With regard to the risk of adenoma recurrence, the long-term follow–up is similar to that of cases of other pituitary adenomas necessary.

Key words:
resistance to thyroid hormone – TSH secreting adenoma – thyreotropin

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