Ganglioneuróm s perineurálnou diferenciáciou. Kazuistika

Prezentovaný je prípad ganglioneurómu s neobvyklou perineurálnou diferenciáciou. Jednalo sa o tumor mediastína u 34-ročného muža. Histologicky obsahoval neuroidné zväzky blandných vretenovitých buniek, zrelé gangliové bunky a ložiskovú adipocytárnu metapláziu. Imunohistochemicky vykazoval tumor očakávané expresie S100 proteinu, kalretinínu a neurofilament proteinu. Prekvapujúcou bola pozitivita početných buniek na perineurálne markery EMA, klaudín-1 a GLUT-1. Jednalo sa často o bunky v organoidnom usporiadaní okolo S100-pozitívnych schwannoidných zväzkov. Prezentovaný prípad ukazuje, že elementy ganglioneurómu sa môžu diferencovať do fenotypu bunky Schwannovej i perineurálnej.

Kľúčové slová:
ganglioneuróm – perineurióm – EMA – claudin-1 – GLUT-1

Autoři: M. Zámečník ¹; A. Chlumská ^2,3; F. Ondriaš ¹
Působiště autorů: Alpha Medical Pathology, s. r. o., Bratislava, Slovak Republic ¹; Šikl`s Department of Pathology, Faculty Hospital, Charles University, Pilsen, Czech Republic ²; Laboratory of Surgical Pathology, Pilsen, Czech Republic ³
Vyšlo v časopise: Čes.-slov. Patol., 48, 2012, No. 2, p. 94-96
Kategorie: Původní práce

Souhrn

Kľúčové slová:
ganglioneuróm – perineurióm – EMA – claudin-1 – GLUT-1

Zdroje

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