Human Population Differentiation Is Strongly Correlated with Local Recombination Rate

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Allele frequency differences across populations can provide valuable information both for studying population structure and for identifying loci that have been targets of natural selection. Here, we examine the relationship between recombination rate and population differentiation in humans by analyzing two uniformly-ascertained, whole-genome data sets. We find that population differentiation as assessed by inter-continental F_ST shows negative correlation with recombination rate, with F_ST reduced by 10% in the tenth of the genome with the highest recombination rate compared with the tenth of the genome with the lowest recombination rate (P≪10⁻¹²). This pattern cannot be explained by the mutagenic properties of recombination and instead must reflect the impact of selection in the last 100,000 years since human continental populations split. The correlation between recombination rate and F_ST has a qualitatively different relationship for F_ST between African and non-African populations and for F_ST between European and East Asian populations, suggesting varying levels or types of selection in different epochs of human history.

Vyšlo v časopise: Human Population Differentiation Is Strongly Correlated with Local Recombination Rate. PLoS Genet 6(3): e32767. doi:10.1371/journal.pgen.1000886
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1000886

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