#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Upsetting the Dogma: Germline Selection in Human Males

English version České info

article has not abstract

Vyšlo v časopise: Upsetting the Dogma: Germline Selection in Human Males. PLoS Genet 8(2): e32767. doi:10.1371/journal.pgen.1002535
Kategorie: Perspective
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1002535

Souhrn

article has not abstract

Zdroje

1. WeinbergW 1912 Zur vererbung des zwergwuchses. Arch Rassen-u Gesell Biolog 9 710 718

2. CrowJF 2000 The origins, patterns and implications of human spontaneous mutation. Nat Rev Genet 1 40 47

3. GorielyAMcVeanGATRöjmyrMIngemarssonBWilkieAOM 2003 Evidence for selective advantage of pathogenic FGFR2 mutations in the male germ line. Science 301 643 646

4. ChoiS-KYoonS-RCalabresePArnheimN 2008 A germ-line-selective advantage rather than an increased mutation rate can explain some unexpectedly common human disease mutations. Proc Nat Acad Sci USA 105 10143 10148

5. ChoiS-KYoonS-RCalabresePArnheimN 2012 Positive selection for new disease mutations in the human germline: evidence from the heritable cancer syndrome multiple endocrine neoplasia type 2B. PLoS Genet 8 e1002420 doi:10.1371/journal.pgen.1002420

6. HaldaneJBS 1931 The causes of evolution New York Harper and Brothers 123

Štítky

Genetika Reprodukčná medicína

Článek A Strong Deletion Bias in Nonallelic Gene Conversion

Článek Positive Selection for New Disease Mutations in the Human Germline: Evidence from the Heritable Cancer Syndrome Multiple Endocrine Neoplasia Type 2B

Článek Genome-Wide Association Study in East Asians Identifies Novel Susceptibility Loci for Breast Cancer

Článek Mixed Effects Modeling of Proliferation Rates in Cell-Based Models: Consequence for Pharmacogenomics and Cancer

Článek Reduction of NADPH-Oxidase Activity Ameliorates the Cardiovascular Phenotype in a Mouse Model of Williams-Beuren Syndrome

Článek Genome-Wide Association Study Identifies Chromosome 10q24.32 Variants Associated with Arsenic Metabolism and Toxicity Phenotypes in Bangladesh

Článek Structural Basis of Transcriptional Gene Silencing Mediated by MOM1

Článek Genomic Restructuring in the Tasmanian Devil Facial Tumour: Chromosome Painting and Gene Mapping Provide Clues to Evolution of a Transmissible Tumour

Článek Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations

Článek Contrasting Properties of Gene-Specific Regulatory, Coding, and Copy Number Mutations in : Frequency, Effects, and Dominance

Článek The Origin and Nature of Tightly Clustered Deletions in Precursor B-Cell Acute Lymphoblastic Leukemia Support a Model of Multiclonal Evolution

Článek Ultrafast Evolution and Loss of CRISPRs Following a Host Shift in a Novel Wildlife Pathogen,

Článek Phosphorylation of Chromosome Core Components May Serve as Axis Marks for the Status of Chromosomal Events during Mammalian Meiosis

Článek Psoriasis Patients Are Enriched for Genetic Variants That Protect against HIV-1 Disease

Článek A Pathogenic Mechanism in Huntington's Disease Involves Small CAG-Repeated RNAs with Neurotoxic Activity

Článek The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity

Článek Homeobox Genes Critically Regulate Embryo Implantation by Controlling Paracrine Signaling between Uterine Stroma and Epithelium

Článek Developmental Transcriptional Networks Are Required to Maintain Neuronal Subtype Identity in the Mature Nervous System

Článek Down-Regulating Sphingolipid Synthesis Increases Yeast Lifespan

Článek Gene Expression and Stress Response Mediated by the Epigenetic Regulation of a Transposable Element Small RNA

Článek Loss of Tgif Function Causes Holoprosencephaly by Disrupting the Shh Signaling Pathway

Článek Sequestration of Highly Expressed mRNAs in Cytoplasmic Granules, P-Bodies, and Stress Granules Enhances Cell Viability

Článek Discovery of a Modified Tetrapolar Sexual Cycle in and the Evolution of in the Species Complex

Článek The Role of Glypicans in Wnt Inhibitory Factor-1 Activity and the Structural Basis of Wif1's Effects on Wnt and Hedgehog Signaling

Článek Nondisjunction of a Single Chromosome Leads to Breakage and Activation of DNA Damage Checkpoint in G2

Článek A Regulatory Network for Coordinated Flower Maturation

Článek Coexpression Network Analysis in Abdominal and Gluteal Adipose Tissue Reveals Regulatory Genetic Loci for Metabolic Syndrome and Related Phenotypes

Článek Diced Triplets Expose Neurons to RISC

Článek The Williams-Beuren Syndrome—A Window into Genetic Variants Leading to the Development of Cardiovascular Disease

Článek The Empirical Power of Rare Variant Association Methods: Results from Sanger Sequencing in 1,998 Individuals

Článek Systematic Detection of Epistatic Interactions Based on Allele Pair Frequencies

Článek Familial Identification: Population Structure and Relationship Distinguishability

Článek Raf1 Is a DCAF for the Rik1 DDB1-Like Protein and Has Separable Roles in siRNA Generation and Chromatin Modification

Článek Loss of Function of the Cik1/Kar3 Motor Complex Results in Chromosomes with Syntelic Attachment That Are Sensed by the Tension Checkpoint

Článek Computational Prediction and Molecular Characterization of an Oomycete Effector and the Cognate Resistance Gene

Článek The Dynamics and Prognostic Potential of DNA Methylation Changes at Stem Cell Gene Loci in Women's Cancer

Článek GTPase Activity and Neuronal Toxicity of Parkinson's Disease–Associated LRRK2 Is Regulated by ArfGAP1

Článek Evaluation of the Role of Functional Constraints on the Integrity of an Ultraconserved Region in the Genus

Článek Neurophysiological Defects and Neuronal Gene Deregulation in Mutants

Článek Genetic and Functional Analyses of Mutations Suggest a Multiple Hit Model of Autism Spectrum Disorders

Článek Negative Supercoiling Creates Single-Stranded Patches of DNA That Are Substrates for AID–Mediated Mutagenesis

Článek Rewiring of PDZ Domain-Ligand Interaction Network Contributed to Eukaryotic Evolution

Článek The Eph Receptor Activates NCK and N-WASP, and Inhibits Ena/VASP to Regulate Growth Cone Dynamics during Axon Guidance

Článek Repression of a Potassium Channel by Nuclear Hormone Receptor and TGF-β Signaling Modulates Insulin Signaling in

Článek The Retrohoming of Linear Group II Intron RNAs in Occurs by Both DNA Ligase 4–Dependent and –Independent Mechanisms

Článek Cell Lineage Analysis of the Mammalian Female Germline

Článek Association of a Functional Variant in the Wnt Co-Receptor with Early Onset Ileal Crohn's Disease

Článok vyšiel v časopise

PLOS Genetics

2012 Číslo 2

Najčítanejšie tento týždeň

Najčítanejšie v tomto čísle

Kurzy

Zvýšte si kvalifikáciu online z pohodlia domova

Aktuální možnosti diagnostiky a léčby litiáz

nový kurz

Autori: MUDr. Tomáš Ürge, PhD.

#ADS_BOTTOM_SCRIPTS#