Comparison of two cash transfer strategies to prevent catastrophic costs for poor tuberculosis-affected households in low- and middle-income countries: An economic modelling study

1. World Health Organization. Global tuberculosis report 2016 [Internet]. 2016 [cited 11 Oct 2017]. Available: http://apps.who.int/iris/bitstream/10665/250441/1/9789241565394-eng.pdf?ua=1

2. Zhang T, Tang S, Jun G, Whitehead M. Persistent problems of access to appropriate, affordable TB services in rural China: experiences of different socio-economic groups. BMC Public Health. 2007;7: 19. doi: 10.1186/1471-2458-7-19 17288593

3. Ukwaja KN, Modebe O, Igwenyi C, Alobu I. The economic burden of tuberculosis care for patients and households in Africa: a systematic review. Int J Tuberc Lung Dis. 2012;16: 733–739. doi: 10.5588/ijtld.11.0193 22410546

4. Laokri S, Dramaix-Wilmet M, Kassa F, Anagonou S, Dujardin B. Assessing the economic burden of illness for tuberculosis patients in Benin: determinants and consequences of catastrophic health expenditures and inequities. Trop Med Int Health. 2014;19: 1249–1258. doi: 10.1111/tmi.12365 25040399

5. Lönnroth K, Aung T, Maung W, Kluge H, Uplekar M. Social franchising of TB care through private GPs in Myanmar: an assessment of treatment results, access, equity and financial protection. Health Policy Plan. 2007;22: 156–166. doi: 10.1093/heapol/czm007 17434870

6. Pantoja A, Lönnroth K, Lal SS, Chauhan LS, Uplekar M, Padma MR, et al. Economic evaluation of public-private mix for tuberculosis care and control, India. Part II. Cost and cost-effectiveness. Int J Tuberc Lung Dis. 2009;13: 705–712. 19460245

7. Tanimura T, Jaramillo E, Weil D, Raviglione M, Lönnroth K. Financial burden for tuberculosis patients in low- and middle-income countries: a systematic review. Eur Respir J. 2014;43: 1763–1775. doi: 10.1183/09031936.00193413 24525439

8. Laurence YV, Griffiths UK, Vassall A. Costs to Health Services and the Patient of Treating Tuberculosis: A Systematic Literature Review. PharmacoEconomics. 2015;33: 939–55. doi: 10.1007/s40273-015-0279-6 25939501

9. Lawn SD, Shattock RJ, Griffin GE. Delays in the diagnosis of tuberculosis: a great new cost. Int J Tuberc Lung Dis Off J Int Union Tuberc Lung Dis. 1997;1: 485–486.

10. Needham DM, Godfrey-Faussett P, Foster SD. Barriers to tuberculosis control in urban Zambia: the economic impact and burden on patients prior to diagnosis. Int J Tuberc Lung Dis. 1998;2: 811–817. 9783528

11. Ukwaja KN, Alobu I, Abimbola S, Hopewell PC. Household catastrophic payments for tuberculosis care in Nigeria: incidence, determinants, and policy implications for universal health coverage. Infect Dis Poverty. 2013;2. doi: 10.1186/2049-9957-2-21 24044368

12. Laokri S, Weil O, Drabo KM, Dembelé SM, Kafando B, Dujardin B. Removal of user fees no guarantee of universal health coverage: observations from Burkina Faso. Bull World Health Organ. 2013;91: 277–282. doi: 10.2471/BLT.12.110015 23599551

13. Zhou C, Long Q, Chen J, Xiang L, Li Q, Tang S, et al. Factors that determine catastrophic expenditure for tuberculosis care: a patient survey in China. Infect Dis Poverty. 2016;5. doi: 10.1186/s40249-016-0100-6 26806552

14. Wingfield T, Boccia D, Tovar M, Gavino A, Zevallos K, Montoya R, et al. Defining Catastrophic Costs and Comparing Their Importance for Adverse Tuberculosis Outcome with Multi-Drug Resistance: A Prospective Cohort Study, Peru. PLoS Med. 2014;11: e1001675. doi: 10.1371/journal.pmed.1001675 25025331

15. Wingfield T, Tovar MA, Huff D, Boccia D, Montoya R, Ramos E, et al. The economic effects of supporting tuberculosis-affected households in Peru. Eur Respir J. 2016;50. doi: 10.1183/13993003.00066–2016

16. Madan J, Lönnroth K, Laokri S, Squire SB. What can dissaving tell us about catastrophic costs? Linear and logistic regression analysis of the relationship between patient costs and financial coping strategies adopted by tuberculosis patients in Bangladesh, Tanzania and Bangalore, India. BMC Health Serv Res. 2015;15. doi: 10.1186/s12913-015-1138-z 26493155

17. World Health Organization. End TB Strategy [Internet]. 2015 [cited 11 Oct 2017]. Available: http://www.who.int/entity/tb/post2015_TBstrategy.pdf

18. The WHO Global Task Force on TB Impact Measurement. Mandate and strategic areas of work in the post-2015 era of the SDGs and End TB Strategy: A proposal for the period 2016–2020 [Internet]. [cited 11 Oct 2017]. Available: http://www.who.int/tb/advisory_bodies/impact_measurement_taskforce/meetings/tf6_background_1_mandate_strategic_areas_work.pdf?ua=1

19. Lönnroth K, Glaziou P, Weil D, Floyd K, Uplekar M, Raviglione M. Beyond UHC: Monitoring Health and Social Protection Coverage in the Context of Tuberculosis Care and Prevention. PLoS Med. 2014;11. doi: 10.1371/journal.pmed.1001693 25243782

20. Wingfield T, Tovar MA, Huff D, Boccia D, Montoya R, Ramos E, et al. A randomized controlled study of socioeconomic support to enhance tuberculosis prevention and treatment, Peru. Bull World Health Organ. 2017;95: 270–280. http://dx.doi.org/10.2471/BLT.16.170167 doi: 10.2471/BLT.16.170167 28479622

21. Kabeer N, Waddington H. Economic impacts of conditional cash transfer programmes: a systematic review and meta-analysis. J Dev Eff. 2015;7: 290–303. http://dx.doi.org/10.1080/19439342.2015.1068833

22. Lagarde M, Haines A, Palmer N. The impact of conditional cash transfers on health outcomes and use of health services in low and middle income countries. Cochrane Database Syst Rev. 2009; CD008137. doi: 10.1002/14651858.CD008137 19821444

23. Bastagli F, Hagen-Zanker J, Harman L, Barka V, Sturge G, Schmidt T, et al. Cash transfers: what does the evidence say? A rigorous review of impacts and the role of design and implementation features [Internet]. Overseas Development Institute; 2016 Jul. Available: https://www.odi.org/sites/odi.org.uk/files/resource-documents/11316.pdf

24. Boccia D, Pedrazzoli D, Wingfield T, Jaramillo E, Lönnroth K, Lewis J, et al. Towards cash transfer interventions for tuberculosis prevention, care and control: key operational challenges and research priorities. BMC Infect Dis. 2016;16. doi: 10.1186/s12879-016-1529-8 27329161

25. Wingfield T, Boccia D, Tovar MA, Huff D, Montoya R, Lewis JJ, et al. Designing and implementing a socioeconomic intervention to enhance TB control: operational evidence from the CRESIPT project in Peru. BMC Public Health. 2015;15. doi: 10.1186/s12889-015-2128-0 26293238

26. Evans CA. PREVENT TB: Improving determinants of TB cure, prevention & diagnosis [Internet]. 2016 Oct [cited 11 Oct 2017]. Available: http://www.isrctn.com/ISRCTN17820976

27. Fiszbein A, Schady N, Ferreira FHG, Grosh M, Keleher N, Olinto P, et al. Conditional cash transfers: reducing present and future poverty. Washington, DC: World Bank Publications; 2009.

28. Gazola Hellmann A. How Does Bolsa Familia Work? [Internet]. Washington, DC: Inter-American Development Bank; 2015 Sep. Report No.: 856. Available: https://publications.iadb.org/bitstream/handle/11319/7210/How_does_Bolsa_Familia_Work.pdf?sequence=5&isAllowed=y

29. World Health Organization. Tuberculosis [Internet]. [cited 11 Oct 2017]. Available: http://www.who.int/mediacentre/factsheets/fs104/en/

30. Husereau D, Drummond M, Petrou S, Carswell C, Moher D, Greenberg D, et al. Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement. Eur J Health Econ. 2013;14: 367–372. doi: 10.1007/s10198-013-0471-6 23526140

31. Rudgard W. Mitigating costs Incurred by tuberculosis patients in low and middle income countries: the role of cash transfer programmes [Internet]. 2015 [cited 11 Oct 2017]. Available: http://library.lshtm.ac.uk/MSc_CID/2014-15/108333.pdf

32. World Health Organization. The Stop TB Strategy [Internet]. 2010 [cited 11 Oct 2017]. Available: http://www.who.int/entity/tb/publications/2010/strategy_en.pdf

33. Steffen R, Menzies D, Oxlade O, Pinto M, de Castro AZ, Monteiro P, et al. Patients’ Costs and Cost-Effectiveness of Tuberculosis Treatment in DOTS and Non-DOTS Facilities in Rio de Janeiro, Brazil. PLoS ONE. 2010;5. https://doi.org/10.1371/journal.pone.0014014

34. Othman GQ, Ibrahim MIM, Raja’a YA. Costs associated with tuberculosis diagnosis and treatment in Yemen for patients and public health services. East Mediterr Health J Rev Santé Méditerranée Orient Al-Majallah Al-Ṣiḥḥīyah Li-Sharq Al-Mutawassiṭ. 2012;18: 393–398.

35. Honorati M, Gentilini U, Yemtsov RG. The State of Social Safety Nets 2015 [Internet]. 2015 [cited 11 Oct 2017]. Available: http://documents.worldbank.org/curated/en/415491467994645020/pdf/97882-PUB-REVISED-Box393232B-PUBLIC-DOCDATE-6-29-2015-DOI-10-1596978-1-4648-0543-1-EPI-1464805431.pdf

36. Social Development Division, Economic Commission for Latin America and the Caribbean of the United Nations (ECLAC). Bolsa Familia (2003-)—Conditional Cash Transfer Programmes—Non-contributory social protection programmes in Latin America and the Caribbean database [Internet]. 2017 [cited 11 Oct 2017]. Available: http://dds.cepal.org/bdptc/en/program/?id=6#

37. Cruz M, Ziegelhofer Z. Beyond the income effect: impacts of conditional cash transfer programs on private investments in human capital [Internet]. 2014 May [cited 11 Oct 2017]. Available: http://documents.worldbank.org/curated/en/2014/05/19520425/beyond-income-effect-impacts-conditional-cash-transfer-programs-private-investments-human-capital

38. Social Development Division, Economic Commission for Latin America and the Caribbean of the United Nations (ECLAC). Bono de Desarrollo Humano (Human Development Grant) (2003-)—Conditional Cash Transfer Programmes—Non-contributory social protection programmes in Latin America and the Caribbean database [Internet]. 2017 [cited 11 Oct 2017]. Available: http://dds.cepal.org/bdptc/en/program/?id=15

39. IPC-IG UNICEF Yemen. Yemen National Social Protection Monitoring Survey (NSPMS): 2012–2013 Final Report [Internet]. 2014 Dec [cited 11 Oct 2017]. Available: http://www.ipc-undp.org/pub/eng/Yemen_National_Social_Protection_Monitoring_Survey_2012_2013.pdf

40. Tanzania Government Project Preparation Team. Productuve Social Safety Net (PSSN) Operational Manual [Internet]. 2013 Jan [cited 11 Oct 2017]. Available: http://www.tasaf.go.tz/index.php/reports/tasaf-documemt-archive/publications/158-tasaf-iii-pssn-operational-manual/file

41. Tanzania Social Action Fund. Tanzania Social Action Fund Condtional Cash Transfer [Internet]. 2017 [cited 11 Oct 2017]. Available: http://tasaf.org/index.php/tasaf-components/supported-interventions/conditional-cash-transfer

42. Evans DK, Hausladen S, Kosec K, Reese N. Community based conditional cash transfers in Tanzania: results from a randomized trial [Internet]. 2014 Mar [cited 11 Oct 2017]. Available: https://doi.org/10.1596/978-1-4648-0141-9

43. van de Meerendonk A, Behrendt C, Kauffmann VW. Rationalizing social protection expenditure in Ghana [Internet]. 2015 [cited 11 Oct 2017]. Available: http://www.ilo.org/wcmsp5/groups/public/—ed_protect/—soc_sec/documents/publication/wcms_431794.pdf

44. Ospina M. The Indirect Effects of Conditional Cash Transfer Programs: An Empirical Analysis of Familias En Accion [Internet]. 2010 [cited 11 Oct 2017]. Available: http://scholarworks.gsu.edu/cgi/viewcontent.cgi?article=1059&context=econ_diss

45. Social Development Division, Economic Commission for Latin America and the Caribbean of the United Nations (ECLAC). Más Familias en Acción (More Families in Action) (2001-)—Conditional Cash Transfer Programmes—Non-contributory social protection programmes in Latin America and the Caribbean database [Internet]. 2017 [cited 11 Oct 2017]. Available: http://dds.cepal.org/bdptc/en/program/?id=12

46. Social Development Division, Economic Commission for Latin America and the Caribbean of the United Nations (ECLAC). Oportunidades (Human Development Programme, formerly “Progresa“) (1997–2014)—Conditional Cash Transfer Programmes—Non-contributory social protection programmes in Latin America and the Caribbean database [Internet]. 2017 [cited 11 Oct 2017]. Available: http://dds.cepal.org/bdptc/en/program/?id=22

47. Angelucci MA, Attanasio O, Di Maro V. The Impact of Oportunidades on Consumption, Savings and Transfers. Fisc Stud. 2012;33: 305–334. doi: 10.1111/j.1475-5890.2012.00163.x

48. International Household Survey Network (IHSN). IHSN Survey Catalog [Internet]. [cited 11 Oct 2017]. Available: http://catalog.ihsn.org/index.php/catalog

49. World Health Organization. Tuberculosis data [Internet]. [cited 11 Oct 2017]. Available: http://www.who.int/tb/country/en/

50. Oxlade O, Murray M. Tuberculosis and Poverty: Why Are the Poor at Greater Risk in India? PLoS ONE. 2012;7. doi: 10.1371/journal.pone.0047533 23185241

51. Ataguba JE, Akazili J, McIntyre D. Socioeconomic-related health inequality in South Africa: evidence from General Household Surveys. Int J Equity Health. 2011;10. doi: 10.1186/1475-9276-10-48 22074349

52. United Nations Statistics Division. Population Censuses’ Datasets (1995—Present) [Internet]. [cited 11 Oct 2017]. Available: http://unstats.un.org/unsd/demographic/products/dyb/dybcensusdata.htm

53. The World Bank. Inflation, consumer prices (annual %) [Internet]. [cited 11 Oct 2017]. Available: https://data.worldbank.org/indicator/FP.CPI.TOTL.ZG?end=2013&start=1960

54. The World Bank. PPP conversion factor, GDP (LCU per international $) [Internet]. [cited 11 Oct 2017]. Available: http://data.worldbank.org/indicator/PA.NUS.PPP

55. Instituto Brasileiro de Geografia e Estatística (IBGE). Pesquisa de Orçamentos Familiares 2008–2009: Despesas, rendimentos e condições de vida [Internet]. [cited 11 Oct 2017]. Available: ftp://ftp.ibge.gov.br/Orcamentos_Familiares/Pesquisa_de_Orcamentos_Familiares_2008_2009/Despesas_rendimentos_e_condicoes_de_vida/tab_rendimentos.zip

56. Instituto Nacional de Estadística y Censos. Encuesta Nacional de Ingresos y Gastos de los Hogares Urbanos y Rurales [Internet]. [cited 11 Oct 2017]. Available: http://www.ecuadorencifras.gob.ec//documentos/web-inec/Estadisticas_Sociales/Encuesta_Nac_Ingresos_Gastos_Hogares_Urb_Rur_ENIGHU/ENIGHU-2011-2012/TABULADOS%20ENIGHUR%202011-2012.xlsx

57. Yemen, Rep. Central Statistical Organization. Household Budget Survey 2005–2006 [Internet]. [cited 11 Oct 2017]. Available: http://catalog.ihsn.org/index.php/catalog/230

58. Ghana Statistical Service. Ghana Living Standard Survey 5: 2005 [Internet]. 2008 Sep [cited 11 Oct 2017]. Available: http://www.statsghana.gov.gh/docfiles/glss5_report.pdf

59. Tanzania National Bureau of Statistics. National Household Budget Survey 2007 [Internet]. [cited 11 Oct 2017]. Available: http://www.ilo.org/surveydata/index.php/catalog/508/download/5091

60. Departamento Administrativo Nacional De Estadística (DANE). Encuesta Nacional de Ingresos y Gastos de los Hogares [Internet]. [cited 11 Oct 2017]. Available: https://www.dane.gov.co/files/investigaciones/condiciones_vida/ingresos_gastos/Cuadros_Total_Nacional_ENIG0607.xls

61. Instituto Nacional de Estadística y Geografía (INEGI). Encuesta Nacional de Ingresos y Gastos de los Hogares (ENIGH) 2010 Nueva construcción [Internet]. [cited 11 Oct 2017]. Available: http://www.beta.inegi.org.mx/contenidos/proyectos/enchogares/regulares/enigh/nc/2010/tabulados/tabulados_2010_ncv.xls

62. Cusmano LG, Palmero DJ, Pereyra AL, Logran M, Morua S. Estudio de los costos intangibles y de la participación del componente familiar en el costo social de la tuberculosis. Rev Argent Salud Publica. 2009;1: 18–23.

63. Gospodarevskaya E, Tulloch O, Bunga C, Ferdous S, Jonas A, Islam S, et al. Patient costs during tuberculosis treatment in Bangladesh and Tanzania: the potential of shorter regimens. Int J Tuberc Lung Dis. 2014;18: 810–817. doi: 10.5588/ijtld.13.0391 24902557

64. Guzmán-Montes GY, Heras-Ovalles R, Laniado-Laborín R. Indirect patient expenses for antituberculosis treatment in Tijuana, Mexico: is treatment really free? J Infect Dev Ctries. 2009;3: 778–782. doi: 10.3855/jidc.489 20009279

65. Mauch V, Bonsu F, Gyapong M, Awini E, Suarez P, Marcelino B, et al. Free tuberculosis diagnosis and treatment are not enough: patient cost evidence from three continents. Int J Tuberc Lung Dis. 2013;17: 381–387. doi: 10.5588/ijtld.12.0368 23407227

66. Rouzier VA, Oxlade O, Verduga R, Gresely L, Menzies D. Patient and family costs associated with tuberculosis, including multidrug-resistant tuberculosis, in Ecuador. Int J Tuberc Lung Dis. 2010;14: 1316–1322. 20843424

67. Hutton J. Cost-benefit analysis in health care expenditure decision-making. Health Econ. 1992;1: 213–216. doi: 10.1002/hec.4730010403 1341937

68. Tudor Hart J. The Inverse Care Law. The Lancet. 1971;297: 405–412. doi: 10.1016/S0140-6736(71)92410-X

69. Lutge EE, Shey Wiysonge C, Knight SE, Sinclair D, Volmink J. Incentives and enablers for improving patient adherence to tuberculosis diagnosis, prophylaxis, and treatment. Cochrane Database Syst Rev. 2015; doi: 10.1002/14651858.CD007952

70. Torrens AW, Rasella D, Boccia D, Maciel ELN, Nery JS, Olson ZD, et al. Effectiveness of a conditional cash transfer programme on TB cure rate: a retrospective cohort study in Brazil. Trans R Soc Trop Med Hyg. 2016;110: 199–206. doi: 10.1093/trstmh/trw011 26884501

71. White PJ, Garnett GP. Mathematical modelling of the epidemiology of tuberculosis. Adv Exp Med Biol. 2010;673: 127–140. 20632534

72. Pedrazzoli D, Boccia D, Dodd PJ, Lönnroth K, Dowdy DW, Siroka A, et al. Modelling the social and structural determinants of tuberculosis: opportunities and challenges. Int J Tuberc Lung Dis. 2017;21: 957–1007. doi: 10.5588/ijtld.16.0906 28826444

73. Pedrazzoli D, Houben RM, Grede N, de Pee S, Boccia D. Food assistance to tuberculosis patients: lessons from Afghanistan. Public Health Action. 2016;6: 147–153. doi: 10.5588/pha.15.0076 27358810

74. International Labour Organization. World Social Protection Report 2014–15: Building economic recovery, inclusive development and social justice [Internet]. 2014 [cited 11 Oct 2017]. Available: http://www.ilo.org/global/research/global-reports/world-social-security-report/2014/WCMS_245201/lang—en/index.htm

75. Floyd K, Skeva J, Nyirenda T, Gausi F, Salaniponi F. Cost and cost-effectiveness of increased community and primary care facility involvement in tuberculosis care in Lilongwe District, Malawi. Int J Tuberc Lung Dis. 2003;7: S29–S37. 12971652

76. Okello D, Floyd K, Adatu F, Odeke R, Gargioni G. Cost and cost-effectiveness of community-based care for tuberculosis patients in rural Uganda. Int J Tuberc Lung Dis. 2003;7: S72–S79. 12971657

77. Health and Social Protection Action Research & Knowledge Sharing (SPARKS) Network -Rationale, Objectives and Work Plan. Geneva: WHO/HTM/TB; 2017.

78. Vassall A, Remme M, Watts C, Hallett T, Siapka M, Vickerman P, et al. Financing Essential HIV Services: A New Economic Agenda. PLoS Med. 2013;10. doi: 10.1371/journal.pmed.1001567 24358028

79. Remme M, Vassall A, Lutz B, Luna J, Watts C. Financing structural interventions: going beyond HIV-only value for money assessments. AIDS. 2014;28: 425–434. doi: 10.1097/QAD.0000000000000076 24670525

80. Siroka A, Ponce NA, Lönnroth K. Association between spending on social protection and tuberculosis burden: a global analysis. Lancet Infect Dis. 2015;16: 473–9. doi: 10.1016/S1473-3099(15)00401-6 26725446

81. Adeyi O, Darley S, Floyd K, Dye C, Klein E, Laxminarayan R. Economic benefit of tuberculosis control. World Bank Publications; 2007.

82. Alam K, Mahal A. Economic impacts of health shocks on households in low and middle income countries: a review of the literature. Glob Health. 2014;10: 21. doi: 10.1186/1744-8603-10-21 24708831

83. Kankeu HT, Saksena P, Xu K, Evans DB. The financial burden from non-communicable diseases in low- and middle-income countries: a literature review. Health Res Policy Syst. 2013;11: 31. doi: 10.1186/1478-4505-11-31 23947294