#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Virological response and resistance among HIV-infected children receiving long-term antiretroviral therapy without virological monitoring in Uganda and Zimbabwe: Observational analyses within the randomised ARROW trial


In an analysis based on the ARROW trial, Alex Szubert and colleagues report on virological and drug resistance outcomes in children with HIV infection.


Vyšlo v časopise: Virological response and resistance among HIV-infected children receiving long-term antiretroviral therapy without virological monitoring in Uganda and Zimbabwe: Observational analyses within the randomised ARROW trial. PLoS Med 14(11): e32767. doi:10.1371/journal.pmed.1002432
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pmed.1002432

Souhrn

In an analysis based on the ARROW trial, Alex Szubert and colleagues report on virological and drug resistance outcomes in children with HIV infection.


Zdroje

1. Joint United Nations Programme on HIV/AIDS. 90-90-90: an ambitious treatment target to help end the AIDS epidemic. Geneva: 2014.

2. Joint United Nations Programme on HIV/AIDS. AIDS by the numbers. 2016. http://www.unaids.org/sites/default/files/media_asset/AIDS-by-the-numbers-2016_en.pdf.

3. World Health Organization. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: Recommendations for a public health approach. 2016. http://apps.who.int/iris/bitstream/10665/208825/1/9789241549684_eng.pdf.

4. Joint United Nations Programme on HIV/AIDS. Diagnostics access initiative to achieve the 90-90-90 treatment target. 2015. http://www.unaids.org/sites/default/files/media_asset/20150422_diagnostics_access_initiative.pdf.

5. Sigaloff KCE, Calis JCJ, Geelen SP, van Vugt M, de Wit TFR. HIV-1-resistance-associated mutations after failure of first-line antiretroviral treatment among children in resource-poor regions: a systematic review. Lancet Infect Dis. 2011;11:769–79. doi: 10.1016/S1473-3099(11)70141-4 21872531

6. World Health Organization. WHO HIV drug resistance report 2012. Geneva: 2012.

7. Paton NI, Kityo C, Hoppe A, Reid A, Kambugu A, Lugemwa A, et al. Assessment of Second-Line Antiretroviral Regimens for HIV Therapy in Africa. N Engl J Med. 2014;371(3):234–47. doi: 10.1056/NEJMoa1311274 25014688

8. ARROW Trial team. Routine vs clinically driven laboratory monitoring and first-line antiretroviral therapy strategies in African children with HIV (ARROW): a 5-year open-label randomised factorial trial. Lancet. 2013;381(9875):1391–403. doi: 10.1016/S0140-6736(12)62198-9 23473847

9. Musiime V, Kasirye P, Naidoo-James B, Nahirya-Ntege P, Mhute T, Cook A, et al. Once- versus twice-daily abacavir and lamivudine in African children: the randomised controlled ARROW Trial. AIDS. 2016;30(11):1761–70. doi: 10.1097/QAD.0000000000001116 27064996

10. World Health Organization. Antiretroviral therapy for HIV infection in infants and children: Towards universal access. Recommendations for a public health approach. 2006. http://www.who.int/hiv/pub/guidelines/paediatric020907.pdf.

11. Johnson VA, Calvez V, Günthard HF, Paredes R, Pillay D, Shafer RW, et al. Update of the drug resistance mutations in HIV-1: March 2013. Top Antivir Med. 2013;21(1):6–14. 23596273

12. Tang MW, Liu TF, Shafer RW. The HIVdb System for HIV-1 Genotypic Resistance Interpretation. Intervirology. 2012;55:98–101. doi: 10.1159/000331998 22286876

13. World Health Organization. Antiretroviral therapy for HIV infection in infants and children: Towards universal access. Recommendations for a public health approach. 2010. http://www.who.int/hiv/pub/guidelines/paediatric020907.pdf.

14. De Onis M, Onyango AW, Borghi E, Siyam A, Nishida C, Siekmanna J. Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ. 2007;85:660–7. doi: 10.2471/BLT.07.043497 18026621

15. Wade A, Ades A. Age-related reference ranges: significance tests for models and confidence intervals for centiles. Stat Med. 1994;13:2359–67. 7855469

16. Wamalwa DC, Lehman DA, Benki-Nugent S, Gasper MA, Gichohi R, Maleche-Obimbo E, et al. Long-Term Virologic Response and Genotypic Resistance Mutations in HIV-1 Infected Kenyan Children on Combination Antiretroviral Therapy. J Acquir Immune Defic Syndr. 2013;62(3):267–74. doi: 10.1097/QAI.0b013e31827b4ac8 23196827

17. Sutcliffe CG, van Dijk JH, Bolton C, Persaud D, Moss WJ. Effectiveness of antiretroviral therapy among HIV-infected children in sub-Saharan Africa. Lancet Infect Dis. 2008;8:477–89. doi: 10.1016/S1473-3099(08)70180-4 18652994

18. Ciaranello AL, Chang Y, Margulis AV, Bernstein A, Bassett IV, Losina E, et al. Effectiveness of Pediatric Antiretroviral Therapy in Resource-Limited Settings: A Systematic Review and Meta-analysis. Clin Infect Dis. 2009;49:1915–27. doi: 10.1086/648079 19916798

19. Henrard DL, Phillips JF, Muenz LR, Blatter WA, Wiesner D, Eyster ME, et al. Natural history of HIV-1 cell-free viremia. JAMA. 1995;274(7):554–8. 7629984

20. Mollet L, Li TS, Samri A, Tournay C, Tubiana R, Calvez V, et al. Dynamics of HIV-Specific CD8+ T Lymphocytes with Changes in Viral Load. J Immunol. 2000;165(3):1692–704. 10903781

21. Phillips RE, Rowland-Jones S, Nixon DF, Gotch FM, Edwards JP, Ogunlesi AO, et al. Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Nature. 1991;354:453–9. doi: 10.1038/354453a0 1721107

22. Harrison L, Melvin A, Fiscus S, Saidi Y, Nastouli E, Harper L, et al. HIV-1 Drug Resistance and Second-Line Treatment in Children Randomized to Switch at Low Versus Higher RNA Thresholds. J Acquir Immune Defic Syndr. 2015;70(1):42–53. doi: 10.1097/QAI.0000000000000671 26322666

23. Davies M-A, Moultrie H, Eley B, Rabie H, Cutsem GV, Giddy J, et al. Virologic Failure and Second-Line Antiretroviral Therapy in Children in South Africa—The IeDEA Southern Africa Collaboration. J Acquir Immune Defic Syndr. 2011;56(3):270–8. doi: 10.1097/QAI.0b013e3182060610 21107266

24. Paton NI, Kityo C, Thompson J, Nankya I, Bagenda L, Hoppe A, et al. Nucleoside reverse-transcriptase inhibitor cross-resistance and outcomes from second-line antiretroviral therapy in the public health approach: an observational analysis within the randomised, open-label, EARNEST trial. Lancet HIV 2017 Aug;4(8):e341–e348. Epub 2017 May 8. doi: 10.1016/S2352-3018(17)30065-6 28495562

25. Lecher S, Ellenberger D, Kim AA, Fonjungo PN, Agolory S, Borget MY, et al. Scale-up of HIV Viral Load Monitoring—Seven Sub-Saharan African Countries. MMWR Morb Mortal Wkly Rep. 2015;64(46):1287–90. doi: 10.15585/mmwr.mm6446a3 26605986

26. Joint United Nations Programme on HIV/AIDS. Ambitious treatment targets: writing the final chapter of the AIDS epidemic. 2014. http://www.unaids.org/sites/default/files/media_asset/JC2670_UNAIDS_Treatment_Targets_en.pdf.

27. Hoffmann CJ, Charalambous S, Sim J, Ledwaba J, Schwikkard G, Chaisson RE, et al. Viremia, Resuppression, and Time to Resistance in Human Immunodeficiency Virus (HIV) Subtype C during First-Line Antiretroviral Therapy in South Africa. Clin Infect Dis. 2009;(49):1928–35.

28. Fox Z, Phillips A, Cohen C, Neuhaus J, Baxter J, Emery S, et al. Viral resuppression and detection of drug resistance following interruption of a suppressive non-nucleoside reverse transcriptase inhibitor-based regimen. AIDS. 2008;22(17):2279–89. doi: 10.1097/QAD.0b013e328311d16f 18981767

29. Lee KJ, Shingadia D, Pillay D, Walker AS, Riordan A, Menson E, et al. Transient viral load increases in HIV-infected children in the U.K. and Ireland: what do they mean? Antivir Ther. 2007;12(6):949–56. 17926649

Štítky
Interné lekárstvo

Článok vyšiel v časopise

PLOS Medicine


2017 Číslo 11
Najčítanejšie tento týždeň
Najčítanejšie v tomto čísle
Kurzy

Zvýšte si kvalifikáciu online z pohodlia domova

Aktuální možnosti diagnostiky a léčby litiáz
nový kurz
Autori: MUDr. Tomáš Ürge, PhD.

Všetky kurzy
Prihlásenie
Zabudnuté heslo

Zadajte e-mailovú adresu, s ktorou ste vytvárali účet. Budú Vám na ňu zasielané informácie k nastaveniu nového hesla.

Prihlásenie

Nemáte účet?  Registrujte sa

#ADS_BOTTOM_SCRIPTS#