Plasticity and Redundancy in Proteins Important for Invasion

1. de Koning-Ward TF, Gilson PR, Crabb BS. Advances in molecular genetic systems in malaria. Nat Rev Microbiol. 2015;13(6):373–87. doi: 10.1038/nrmicro3450 25978707

2. Jimenez-Ruiz E, Wong EH, Pall GS, Meissner M. Advantages and disadvantages of conditional systems for characterization of essential genes in Toxoplasma gondii. Parasitology. 2014;141(11):1390–8. doi: 10.1017/S0031182014000559 24926834

3. Carruthers V, Boothroyd JC. Pulling together: an integrated model of Toxoplasma cell invasion. Current opinion in microbiology. 2007;10(1):83–9. 16837236

4. Tyler JS, Treeck M, Boothroyd JC. Focus on the ringleader: the role of AMA1 in apicomplexan invasion and replication. Trends in parasitology. 2011;27(9):410–20. doi: 10.1016/j.pt.2011.04.002 21659001

5. Besteiro S, Michelin A, Poncet J, Dubremetz JF, Lebrun M. Export of a Toxoplasma gondii rhoptry neck protein complex at the host cell membrane to form the moving junction during invasion. PLoS pathogens. 2009;5(2):e1000309. doi: 10.1371/journal.ppat.1000309 19247437

6. Fox BA, Ristuccia JG, Gigley JP, Bzik DJ. Efficient gene replacements in Toxoplasma gondii strains deficient for nonhomologous end joining. Eukaryot Cell. 2009;8(4):520–9. doi: 10.1128/EC.00357-08 19218423

7. Huynh MH, Carruthers VB. Tagging of endogenous genes in a Toxoplasma gondii strain lacking Ku80. Eukaryot Cell. 2009;8(4):530–9. doi: 10.1128/EC.00358-08 19218426.

8. Heaslip AT, Dzierszinski F, Stein B, Hu K. TgMORN1 is a key organizer for the basal complex of Toxoplasma gondii. PLoS pathogens. 2010;6(2):e1000754. doi: 10.1371/journal.ppat.1000754 20140195

9. Andenmatten N, Egarter S, Jackson AJ, Jullien N, Herman JP, Meissner M. Conditional genome engineering in Toxoplasma gondii uncovers alternative invasion mechanisms. Nature methods. 2012. E-pub ahead of print.

10. Meissner M, Schluter D, Soldati D. Role of Toxoplasma gondii myosin A in powering parasite gliding and host cell invasion. Science. 2002;298(5594):837–40. 12399593

11. Herm-Gotz A, Agop-Nersesian C, Munter S, Grimley JS, Wandless TJ, Frischknecht F, et al. Rapid control of protein level in the apicomplexan Toxoplasma gondii. Nature methods. 2007;4(12):1003–5. 17994029

12. Mital J, Meissner M, Soldati D, Ward GE. Conditional expression of Toxoplasma gondii apical membrane antigen-1 (TgAMA1) demonstrates that TgAMA1 plays a critical role in host cell invasion. Molecular biology of the cell. 2005;16(9):4341–9. 16000372

13. Bargieri DY, Andenmatten N, Lagal V, Thiberge S, Whitelaw JA, Tardieux I, et al. Apical membrane antigen 1 mediates apicomplexan parasite attachment but is dispensable for host cell invasion. Nature communications. 2013;4:2552. doi: 10.1038/ncomms3552 24108241

14. Egarter S, Andenmatten N, Jackson AJ, Whitelaw JA, Pall G, Black JA, et al. The toxoplasma Acto-MyoA motor complex is important but not essential for gliding motility and host cell invasion. PloS one. 2014;9(3):e91819. doi: 10.1371/journal.pone.0091819 24632839

15. Frenal K, Marq JB, Jacot D, Polonais V, Soldati-Favre D. Plasticity between MyoC- and MyoA-glideosomes: an example of functional compensation in Toxoplasma gondii invasion. PLoS pathogens. 2014;10(10):e1004504. doi: 10.1371/journal.ppat.1004504 25393004

16. Lamarque MH, Roques M, Kong-Hap M, Tonkin ML, Rugarabamu G, Marq JB, et al. Plasticity and redundancy among AMA-RON pairs ensure host cell entry of Toxoplasma parasites. Nature communications. 2014;5:4098. doi: 10.1038/ncomms5098 24934579

17. Foth BJ, Goedecke MC, Soldati D. New insights into myosin evolution and classification. Proceedings of the National Academy of Sciences of the United States of America. 2006;103(10):3681–6. Epub 2006/03/01. 16505385

18. Jacot D, Frenal K, Marq JB, Sharma P, Soldati-Favre D. Assessment of phosphorylation in Toxoplasma glideosome assembly and function. Cellular microbiology. 2014;16(10):1518–32. doi: 10.1111/cmi.12307 24779470

19. Frenal K, Polonais V, Marq JB, Stratmann R, Limenitakis J, Soldati-Favre D. Functional dissection of the apicomplexan glideosome molecular architecture. Cell host & microbe. 2010;8(4):343–57.

20. Lamarque M, Besteiro S, Papoin J, Roques M, Vulliez-Le Normand B, Morlon-Guyot J, et al. The RON2-AMA1 interaction is a critical step in moving junction-dependent invasion by apicomplexan parasites. PLoS pathogens. 2011;7(2):e1001276. doi: 10.1371/journal.ppat.1001276 21347343

21. Bichet M, Joly C, Henni A, Guilbert T, Xemard M, Tafani V, et al. The toxoplasma-host cell junction is anchored to the cell cortex to sustain parasite invasive force. BMC biology. 2014;12(1):773. doi: 10.1186/s12915-014-0108-y 25551479

22. Poukchanski A, Fritz HM, Tonkin ML, Treeck M, Boulanger MJ, Boothroyd JC. Toxoplasma gondii sporozoites invade host cells using two novel paralogues of RON2 and AMA1. PloS one. 2013;8(8):e70637. doi: 10.1371/journal.pone.0070637 23940612

23. Baum J, Maier AG, Good RT, Simpson KM, Cowman AF. Invasion by P. falciparum merozoites suggests a hierarchy of molecular interactions. PLoS pathogens. 2005;1(4):e37. 16362075

24. Tymoshenko S, Oppenheim RD, Agren R, Nielsen J, Soldati-Favre D, Hatzimanikatis V. Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis. PLoS Comput Biol. 2015;11(5):e1004261. doi: 10.1371/journal.pcbi.1004261 26001086

25. Gubbels MJ, Vaishnava S, Boot N, Dubremetz JF, Striepen B. A MORN-repeat protein is a dynamic component of the Toxoplasma gondii cell division apparatus. J Cell Sci. 2006;119(Pt 11):2236–45.

26. Lorestani A, Sheiner L, Yang K, Robertson SD, Sahoo N, Brooks CF, et al. A Toxoplasma MORN1 null mutant undergoes repeated divisions but is defective in basal assembly, apicoplast division and cytokinesis. PloS one. 2010;5(8):e12302. doi: 10.1371/journal.pone.0012302 20808817

27. Fichera ME, Roos DS. A plastid organelle as a drug target in apicomplexan parasites. Nature. 1997;390(6658):407–9. 9389481

28. Shen B, Brown KM, Lee TD, Sibley LD. Efficient gene disruption in diverse strains of Toxoplasma gondii using CRISPR/CAS9. mBio. 2014;5(3):e01114–14. doi: 10.1128/mBio.01114-14 24825012

29. Sidik SM, Hackett CG, Tran F, Westwood NJ, Lourido S. Efficient genome engineering of Toxoplasma gondii using CRISPR/Cas9. PloS one. 2014;9(6):e100450. doi: 10.1371/journal.pone.0100450 24971596

30. Ghorbal M, Gorman M, Macpherson CR, Martins RM, Scherf A, Lopez-Rubio JJ. Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system. Nat Biotechnol. 2014;32(8):819–21. doi: 10.1038/nbt.2925 24880488

31. Lee MC, Fidock DA. CRISPR-mediated genome editing of Plasmodium falciparum malaria parasites. Genome Med. 2014;6(8):63. doi: 10.1186/s13073-014-0063-9 25473431

32. Wagner JC, Platt RJ, Goldfless SJ, Zhang F, Niles JC. Efficient CRISPR-Cas9-mediated genome editing in Plasmodium falciparum. Nature methods. 2014;11(9):915–8. doi: 10.1038/nmeth.3063 25108687