The influence of testosterone on cardiovascular disease in men

Česká verzia

Authors: J. Payer; A. Baňárová
Authors place of work: V. interná klinika Lekárskej fakulty UK a FNsP Bratislava, Slovenská republika, prednosta prof. MUDr. Juraj Payer, CSc.
Published in the journal: Vnitř Lék 2010; 56(7): 702-708
Category: 80. narozeniny předsedy České lékařské společnosti J. E. Purkyně prof. MUDr. Jaroslava Blahoše, DrSc.

Summary

The influence of testosterone on cardiovascular disease is recently discussed question. Testosterone modulates vascular reactivity by genomic and nongenomic modes of action, it has an impact on endothelial function, production of proinflamatory cytokines and lipid profiles. The possible role of sex hormone binding globulin (SHBG) in androgen action by plasmatic membrane receptors breaks “the free hormone hypothesis”, especially when clinical trials reveal strong association between SHBG and risk factors of cardiovascular disease. The results of last clinical trials mention that androgen deficiency is associated with obesity, insulin resistance and dyslipidaemia. Large clinical trials demonstrated that androgen deficiency predict mortality in elderly men. Testosterone substitution restores vasoreactivity and endothelial function and could potentially reduce cardiovascular disease in men but to confirm this theory more large clinical trials are needed.

Key words:
testosterone – androgen deficiency – endotelial dysfunction – metabolic syndrome

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