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Central and peripheral blo od pressure and their control by tre atment


Authors: J. Filipovský
Published in the journal: Kardiol Rev Int Med 2008, 10(4): 147-151

Summary

Blo od pressure (BP) me asured the normal way from the brachi al artery differs from central BP in the aorta due to different characteristics of the blo od vessel wall and the size of the reflected pressure wave. Central BP can be estimated non‑invasively using pulse wave analysis. Central BP is a better predictor of cardi ovascular events than peripheral BP, especi ally in pati ents with renal insuffici ency, advanced coronary atherosclerosis etc. Different antihypertensive drugs have different effects: beta blockers have less influence on central BP than on peripheral BP, while the influence of ACE inhibitors and probably also sartans on central Bp is gre ater. Central BP is the potenti al future therape utic objective.

Key words:
central blo od pressure –  vascular rigidity –  reflected pressure wave –  pulse wave analysis –  antihypertensive tre atment


Zdroje

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7. London GM, Asmar RG, O’Ro urke MF et al. Mechanism(s) of selective systolic blo od pressure reducti on after a low‑dose combinati on of perindopril/ indapamide in hypertensive subjects: comparison with atenolol. J Am Coll Cardi ol 2004; 43: 92– 99.

8. Willi ams B, Lacy PS, Thom SM et al. Differenti al impact of blo od pressure‑lowering drugs on central aortic pressure and clinical o utcomes: principal results of the Conduit Artery Functi on Evalu ati on (CAFE) Study. Circulati on 2006; 113: 1213– 25.

Štítky
Paediatric cardiology Internal medicine Cardiac surgery Cardiology
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